Is the nocturnal fall in blood pressure reduced in essential hypertensive patients with metabolic syndrome?

Cesare Cuspidi, Stefano Meani, Veronica Fusi, Barbara Severgnini, Cristiana Valerio, Eleonora Catini, Carla Sala, Fabio Magrini, Alberto Zanchetti

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Objective: The aim of this study was to examine whether an impaired reduction in nocturnal blood pressure (BP), defined on the basis of two periods of ambulatory BP monitoring (ABPM), is present in hypertensive patients with metabolic syndrome, as defined by the NCEP criteria. Methods: 460 grade 1 and 2 untreated essential hypertensives (mean age 45.9 ± 11.9 years) referred for the first time to our outpatient hospital clinic underwent the following procedures: 1) medical history and physical examination; 2) repeated clinic BP measurements; 3) routine examinations; 4) ABPM over two 24-hour periods within 4 weeks. Metabolic syndrome was defined as at least three of the following alterations: increased waist circumference, increased triglycerides, decreased HDL-cholesterol, increased BP, or high fasting glucose. Nocturnal dipping was defined as a night-time reduction in average SBP and DBP > 10% compared to average daytime values. Results: The 135 patients with metabolic syndrome (group I) were similar for age, gender and known duration of hypertension to the 325 patients without it (group II). There were no significant differences between the two groups in average 48-hour, daytime, night-time SBP/DBP values and the percentage nocturnal SBP and DBP decrease (-17.7/-15.7 vs.-18.4/-16.2, p = ns). A reproducible nocturnal dipping (decrease in BP > 10% from mean daytime in both ABPM periods) and non-dipping profile (decrease in BP ≤ 10% in both ABPM periods) was found in 74 (54.8%) and 29 (21.4%) in group I and in 169 (52.1%) and 73 (22.4%) in group II, respectively (p = ns); 32 patients (23.7%) in group I and 83 patients (25.5%) in group II had a variable dipping profile (p = ns). Conclusions: This study shows that no significant difference exists in nocturnal BP patterns, assessed by two ABPMs, in untreated essential hypertensive patients with metabolic syndrome compared to those without it.

Original languageEnglish
Pages (from-to)230-235
Number of pages6
JournalBlood Pressure
Volume13
Issue number4
DOIs
Publication statusPublished - 2004

Fingerprint

Blood Pressure
Ambulatory Monitoring
Hospital Outpatient Clinics
Hypertension
Ambulatory Blood Pressure Monitoring
Waist Circumference
HDL Cholesterol
Physical Examination
Fasting
Triglycerides
Glucose

Keywords

  • Hypertension
  • Metabolic syndrome
  • Non-dipping

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Internal Medicine

Cite this

Is the nocturnal fall in blood pressure reduced in essential hypertensive patients with metabolic syndrome? / Cuspidi, Cesare; Meani, Stefano; Fusi, Veronica; Severgnini, Barbara; Valerio, Cristiana; Catini, Eleonora; Sala, Carla; Magrini, Fabio; Zanchetti, Alberto.

In: Blood Pressure, Vol. 13, No. 4, 2004, p. 230-235.

Research output: Contribution to journalArticle

Cuspidi, C, Meani, S, Fusi, V, Severgnini, B, Valerio, C, Catini, E, Sala, C, Magrini, F & Zanchetti, A 2004, 'Is the nocturnal fall in blood pressure reduced in essential hypertensive patients with metabolic syndrome?', Blood Pressure, vol. 13, no. 4, pp. 230-235. https://doi.org/10.1080/08037050410021540
Cuspidi, Cesare ; Meani, Stefano ; Fusi, Veronica ; Severgnini, Barbara ; Valerio, Cristiana ; Catini, Eleonora ; Sala, Carla ; Magrini, Fabio ; Zanchetti, Alberto. / Is the nocturnal fall in blood pressure reduced in essential hypertensive patients with metabolic syndrome?. In: Blood Pressure. 2004 ; Vol. 13, No. 4. pp. 230-235.
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AU - Meani, Stefano

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AU - Valerio, Cristiana

AU - Catini, Eleonora

AU - Sala, Carla

AU - Magrini, Fabio

AU - Zanchetti, Alberto

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N2 - Objective: The aim of this study was to examine whether an impaired reduction in nocturnal blood pressure (BP), defined on the basis of two periods of ambulatory BP monitoring (ABPM), is present in hypertensive patients with metabolic syndrome, as defined by the NCEP criteria. Methods: 460 grade 1 and 2 untreated essential hypertensives (mean age 45.9 ± 11.9 years) referred for the first time to our outpatient hospital clinic underwent the following procedures: 1) medical history and physical examination; 2) repeated clinic BP measurements; 3) routine examinations; 4) ABPM over two 24-hour periods within 4 weeks. Metabolic syndrome was defined as at least three of the following alterations: increased waist circumference, increased triglycerides, decreased HDL-cholesterol, increased BP, or high fasting glucose. Nocturnal dipping was defined as a night-time reduction in average SBP and DBP > 10% compared to average daytime values. Results: The 135 patients with metabolic syndrome (group I) were similar for age, gender and known duration of hypertension to the 325 patients without it (group II). There were no significant differences between the two groups in average 48-hour, daytime, night-time SBP/DBP values and the percentage nocturnal SBP and DBP decrease (-17.7/-15.7 vs.-18.4/-16.2, p = ns). A reproducible nocturnal dipping (decrease in BP > 10% from mean daytime in both ABPM periods) and non-dipping profile (decrease in BP ≤ 10% in both ABPM periods) was found in 74 (54.8%) and 29 (21.4%) in group I and in 169 (52.1%) and 73 (22.4%) in group II, respectively (p = ns); 32 patients (23.7%) in group I and 83 patients (25.5%) in group II had a variable dipping profile (p = ns). Conclusions: This study shows that no significant difference exists in nocturnal BP patterns, assessed by two ABPMs, in untreated essential hypertensive patients with metabolic syndrome compared to those without it.

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