TY - JOUR
T1 - Is the placental proteome impaired in well-controlled gestational diabetes?
AU - Burlina, Silvia
AU - Banfi, Cristina
AU - Brioschi, Maura
AU - Visentin, Silvia
AU - Dalfrà, Maria Grazia
AU - Traldi, Pietro
AU - Lapolla, Annunziata
PY - 2019/4
Y1 - 2019/4
N2 - In pregnancy complicated by gestational diabetes mellitus (GDM), the human placenta shows several pathological functional and structural changes, but the extent to which maternal glycemic control contributes to placental abnormalities remains unclear. The aim of this study was to profile and compare the proteome of placentas from healthy pregnant women and those with GDM, to investigate the placenta-specific protein composition and possible changes of its function in presence of GDM. Quantitative proteomic analysis, based on LC-MS E approach, revealed that higher (approximately 15% increase) levels of galectin 1 and collagen alpha-1 XIV chain (although the difference regarding the latter was at the limit of significance) were present in GDM samples, while heat shock 70 kDa protein 1A/1B was less abundant in GDM placental tissue. These data seem to indicate that GDM, when well controlled, did not markedly affect the placental proteome.
AB - In pregnancy complicated by gestational diabetes mellitus (GDM), the human placenta shows several pathological functional and structural changes, but the extent to which maternal glycemic control contributes to placental abnormalities remains unclear. The aim of this study was to profile and compare the proteome of placentas from healthy pregnant women and those with GDM, to investigate the placenta-specific protein composition and possible changes of its function in presence of GDM. Quantitative proteomic analysis, based on LC-MS E approach, revealed that higher (approximately 15% increase) levels of galectin 1 and collagen alpha-1 XIV chain (although the difference regarding the latter was at the limit of significance) were present in GDM samples, while heat shock 70 kDa protein 1A/1B was less abundant in GDM placental tissue. These data seem to indicate that GDM, when well controlled, did not markedly affect the placental proteome.
KW - gestational diabetes
KW - human placenta
KW - label-free LC-MS analysis
KW - proteomic analysis
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U2 - 10.1002/jms.4336
DO - 10.1002/jms.4336
M3 - Article
C2 - 30675960
AN - SCOPUS:85064177656
VL - 54
SP - 359
EP - 365
JO - Biomedical Mass Spectrometry
JF - Biomedical Mass Spectrometry
SN - 1076-5174
IS - 4
ER -