Is the placental proteome impaired in well-controlled gestational diabetes?

Silvia Burlina, Cristina Banfi, Maura Brioschi, Silvia Visentin, Maria Grazia Dalfrà, Pietro Traldi, Annunziata Lapolla

Research output: Contribution to journalArticlepeer-review

Abstract

In pregnancy complicated by gestational diabetes mellitus (GDM), the human placenta shows several pathological functional and structural changes, but the extent to which maternal glycemic control contributes to placental abnormalities remains unclear. The aim of this study was to profile and compare the proteome of placentas from healthy pregnant women and those with GDM, to investigate the placenta-specific protein composition and possible changes of its function in presence of GDM. Quantitative proteomic analysis, based on LC-MS E approach, revealed that higher (approximately 15% increase) levels of galectin 1 and collagen alpha-1 XIV chain (although the difference regarding the latter was at the limit of significance) were present in GDM samples, while heat shock 70 kDa protein 1A/1B was less abundant in GDM placental tissue. These data seem to indicate that GDM, when well controlled, did not markedly affect the placental proteome.

Original languageEnglish
Pages (from-to)359-365
Number of pages7
JournalJournal of Mass Spectrometry
Volume54
Issue number4
DOIs
Publication statusPublished - Apr 2019

Keywords

  • gestational diabetes
  • human placenta
  • label-free LC-MS analysis
  • proteomic analysis

ASJC Scopus subject areas

  • Spectroscopy

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