Is the prognosis and course of acral melanoma related to site-specific clinicopathological features?

Giovanni Paolino, M W Bekkenk, Dario Didona, L Eibenschutz, Antonio Giovanni Richetta, Maria C. Cantisani, G. Viti, Anna Carbone, Pierluigi Buccini, P De Simone, A Ferrari, E Scali, S. Calvieri, V Silipo, E. Cigna, G P Viti, U. Bottoni

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: Acral melanoma is an uncommon type of melanoma in Caucasian patients. However, acral melanoma is the most common type of melanoma in African and Asian patients. Comparison analyses between hand-acral melanoma and foot-acral melanoma have been rarely reported in the literature. Acral melanoma is an uncommon melanocytic tumor characterized by an intrinsic aggressiveness, with specific histological and clinicopathological features. Acral melanoma involves the palms, soles and sub-ungueal sites.

PATIENTS AND METHODS: A total of 244 patients with acral melanoma were included in our analysis. The current study was performed in three different medical centers: Sapienza University of Rome, San Gallicano Institute of Rome and University of Magna Graecia (Italy). The Kaplan-Meier product was used to estimate survival curves for disease-free survival and overall survival. The log-rank test was used to evaluate differences between the survival curves. Assuming that the effects of the predictor variables are constant over time, the independent predictive factors were assessed by Spearman's test and subsequently data were analyzed performing Cox proportional-hazard regression.

RESULTS: In both univariate and multivariate analyses Breslow thickness (p < 0.0001) and ulceration (p = 0.003) remained the main predictors. General BRAF mutation was detected in 13.8% of cases. We found that median Breslow value and the percentage of recurrences were similar in hand-acral melanoma and foot-acral melanoma, as well as there were no differences in both short and long-term.

CONCLUSIONS: The absence of differences in survival between hand-acral melanoma and foot-acral melanoma shows that the aggressiveness of the disease is related to distinct mutational rate, as well as to anatomical site-specific features, rather than to the visibility of the primary lesion.

Original languageEnglish
Pages (from-to)842-8
Number of pages7
JournalEuropean Review for Medical and Pharmacological Sciences
Volume20
Issue number5
Publication statusPublished - Mar 2016

Fingerprint

Melanoma
Extremities
Foot
Survival
Hand
Italy
Disease-Free Survival
Multivariate Analysis
Recurrence
Mutation

Keywords

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Disease-Free Survival
  • Female
  • Foot
  • Hand
  • Humans
  • Italy
  • Male
  • Melanoma
  • Middle Aged
  • Neoplasm Recurrence, Local
  • Prognosis
  • Rome
  • Skin Neoplasms
  • Young Adult
  • Journal Article
  • Multicenter Study

Cite this

Paolino, G., Bekkenk, M. W., Didona, D., Eibenschutz, L., Richetta, A. G., Cantisani, M. C., ... Bottoni, U. (2016). Is the prognosis and course of acral melanoma related to site-specific clinicopathological features? European Review for Medical and Pharmacological Sciences, 20(5), 842-8.

Is the prognosis and course of acral melanoma related to site-specific clinicopathological features? / Paolino, Giovanni; Bekkenk, M W; Didona, Dario; Eibenschutz, L; Richetta, Antonio Giovanni; Cantisani, Maria C.; Viti, G.; Carbone, Anna; Buccini, Pierluigi; De Simone, P; Ferrari, A; Scali, E; Calvieri, S.; Silipo, V; Cigna, E.; Viti, G P; Bottoni, U.

In: European Review for Medical and Pharmacological Sciences, Vol. 20, No. 5, 03.2016, p. 842-8.

Research output: Contribution to journalArticle

Paolino, G, Bekkenk, MW, Didona, D, Eibenschutz, L, Richetta, AG, Cantisani, MC, Viti, G, Carbone, A, Buccini, P, De Simone, P, Ferrari, A, Scali, E, Calvieri, S, Silipo, V, Cigna, E, Viti, GP & Bottoni, U 2016, 'Is the prognosis and course of acral melanoma related to site-specific clinicopathological features?', European Review for Medical and Pharmacological Sciences, vol. 20, no. 5, pp. 842-8.
Paolino, Giovanni ; Bekkenk, M W ; Didona, Dario ; Eibenschutz, L ; Richetta, Antonio Giovanni ; Cantisani, Maria C. ; Viti, G. ; Carbone, Anna ; Buccini, Pierluigi ; De Simone, P ; Ferrari, A ; Scali, E ; Calvieri, S. ; Silipo, V ; Cigna, E. ; Viti, G P ; Bottoni, U. / Is the prognosis and course of acral melanoma related to site-specific clinicopathological features?. In: European Review for Medical and Pharmacological Sciences. 2016 ; Vol. 20, No. 5. pp. 842-8.
@article{dac716dbd85c4adfb9a1a343b0030fbd,
title = "Is the prognosis and course of acral melanoma related to site-specific clinicopathological features?",
abstract = "OBJECTIVE: Acral melanoma is an uncommon type of melanoma in Caucasian patients. However, acral melanoma is the most common type of melanoma in African and Asian patients. Comparison analyses between hand-acral melanoma and foot-acral melanoma have been rarely reported in the literature. Acral melanoma is an uncommon melanocytic tumor characterized by an intrinsic aggressiveness, with specific histological and clinicopathological features. Acral melanoma involves the palms, soles and sub-ungueal sites.PATIENTS AND METHODS: A total of 244 patients with acral melanoma were included in our analysis. The current study was performed in three different medical centers: Sapienza University of Rome, San Gallicano Institute of Rome and University of Magna Graecia (Italy). The Kaplan-Meier product was used to estimate survival curves for disease-free survival and overall survival. The log-rank test was used to evaluate differences between the survival curves. Assuming that the effects of the predictor variables are constant over time, the independent predictive factors were assessed by Spearman's test and subsequently data were analyzed performing Cox proportional-hazard regression.RESULTS: In both univariate and multivariate analyses Breslow thickness (p < 0.0001) and ulceration (p = 0.003) remained the main predictors. General BRAF mutation was detected in 13.8{\%} of cases. We found that median Breslow value and the percentage of recurrences were similar in hand-acral melanoma and foot-acral melanoma, as well as there were no differences in both short and long-term.CONCLUSIONS: The absence of differences in survival between hand-acral melanoma and foot-acral melanoma shows that the aggressiveness of the disease is related to distinct mutational rate, as well as to anatomical site-specific features, rather than to the visibility of the primary lesion.",
keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Disease-Free Survival, Female, Foot, Hand, Humans, Italy, Male, Melanoma, Middle Aged, Neoplasm Recurrence, Local, Prognosis, Rome, Skin Neoplasms, Young Adult, Journal Article, Multicenter Study",
author = "Giovanni Paolino and Bekkenk, {M W} and Dario Didona and L Eibenschutz and Richetta, {Antonio Giovanni} and Cantisani, {Maria C.} and G. Viti and Anna Carbone and Pierluigi Buccini and {De Simone}, P and A Ferrari and E Scali and S. Calvieri and V Silipo and E. Cigna and Viti, {G P} and U. Bottoni",
year = "2016",
month = "3",
language = "English",
volume = "20",
pages = "842--8",
journal = "European Review for Medical and Pharmacological Sciences",
issn = "1128-3602",
publisher = "Verduci Editore",
number = "5",

}

TY - JOUR

T1 - Is the prognosis and course of acral melanoma related to site-specific clinicopathological features?

AU - Paolino, Giovanni

AU - Bekkenk, M W

AU - Didona, Dario

AU - Eibenschutz, L

AU - Richetta, Antonio Giovanni

AU - Cantisani, Maria C.

AU - Viti, G.

AU - Carbone, Anna

AU - Buccini, Pierluigi

AU - De Simone, P

AU - Ferrari, A

AU - Scali, E

AU - Calvieri, S.

AU - Silipo, V

AU - Cigna, E.

AU - Viti, G P

AU - Bottoni, U.

PY - 2016/3

Y1 - 2016/3

N2 - OBJECTIVE: Acral melanoma is an uncommon type of melanoma in Caucasian patients. However, acral melanoma is the most common type of melanoma in African and Asian patients. Comparison analyses between hand-acral melanoma and foot-acral melanoma have been rarely reported in the literature. Acral melanoma is an uncommon melanocytic tumor characterized by an intrinsic aggressiveness, with specific histological and clinicopathological features. Acral melanoma involves the palms, soles and sub-ungueal sites.PATIENTS AND METHODS: A total of 244 patients with acral melanoma were included in our analysis. The current study was performed in three different medical centers: Sapienza University of Rome, San Gallicano Institute of Rome and University of Magna Graecia (Italy). The Kaplan-Meier product was used to estimate survival curves for disease-free survival and overall survival. The log-rank test was used to evaluate differences between the survival curves. Assuming that the effects of the predictor variables are constant over time, the independent predictive factors were assessed by Spearman's test and subsequently data were analyzed performing Cox proportional-hazard regression.RESULTS: In both univariate and multivariate analyses Breslow thickness (p < 0.0001) and ulceration (p = 0.003) remained the main predictors. General BRAF mutation was detected in 13.8% of cases. We found that median Breslow value and the percentage of recurrences were similar in hand-acral melanoma and foot-acral melanoma, as well as there were no differences in both short and long-term.CONCLUSIONS: The absence of differences in survival between hand-acral melanoma and foot-acral melanoma shows that the aggressiveness of the disease is related to distinct mutational rate, as well as to anatomical site-specific features, rather than to the visibility of the primary lesion.

AB - OBJECTIVE: Acral melanoma is an uncommon type of melanoma in Caucasian patients. However, acral melanoma is the most common type of melanoma in African and Asian patients. Comparison analyses between hand-acral melanoma and foot-acral melanoma have been rarely reported in the literature. Acral melanoma is an uncommon melanocytic tumor characterized by an intrinsic aggressiveness, with specific histological and clinicopathological features. Acral melanoma involves the palms, soles and sub-ungueal sites.PATIENTS AND METHODS: A total of 244 patients with acral melanoma were included in our analysis. The current study was performed in three different medical centers: Sapienza University of Rome, San Gallicano Institute of Rome and University of Magna Graecia (Italy). The Kaplan-Meier product was used to estimate survival curves for disease-free survival and overall survival. The log-rank test was used to evaluate differences between the survival curves. Assuming that the effects of the predictor variables are constant over time, the independent predictive factors were assessed by Spearman's test and subsequently data were analyzed performing Cox proportional-hazard regression.RESULTS: In both univariate and multivariate analyses Breslow thickness (p < 0.0001) and ulceration (p = 0.003) remained the main predictors. General BRAF mutation was detected in 13.8% of cases. We found that median Breslow value and the percentage of recurrences were similar in hand-acral melanoma and foot-acral melanoma, as well as there were no differences in both short and long-term.CONCLUSIONS: The absence of differences in survival between hand-acral melanoma and foot-acral melanoma shows that the aggressiveness of the disease is related to distinct mutational rate, as well as to anatomical site-specific features, rather than to the visibility of the primary lesion.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Disease-Free Survival

KW - Female

KW - Foot

KW - Hand

KW - Humans

KW - Italy

KW - Male

KW - Melanoma

KW - Middle Aged

KW - Neoplasm Recurrence, Local

KW - Prognosis

KW - Rome

KW - Skin Neoplasms

KW - Young Adult

KW - Journal Article

KW - Multicenter Study

M3 - Article

C2 - 27010139

VL - 20

SP - 842

EP - 848

JO - European Review for Medical and Pharmacological Sciences

JF - European Review for Medical and Pharmacological Sciences

SN - 1128-3602

IS - 5

ER -