Is the Real Prevalence of Pancreatic Neuroendocrine Tumors Underestimated? A Retrospective Study on a Large Series of Pancreatic Specimens

Stefano Partelli, Fabio Giannone, Marco Schiavo Lena, Francesca Muffatti, Valentina Andreasi, Stefano Crippa, Domenico Tamburrino, Giuseppe Zamboni, Corrado Rubini, Claudio Doglioni, Massimo Falconi

Research output: Contribution to journalArticlepeer-review

Abstract

Background/Aims: The annual incidence of pancreatic neuroendocrine tumors (PanNET) has been estimated to be around 0.8/100,000 inhabitants. The aim of this study was to determine the frequency of incidental histological diagnosis of PanNET in pancreatic specimen evaluation for a purpose other other than PanNET diagnosis. Methods: One thousand seventy-four histopathological examinations of pancreatic specimens performed in 3 centers in Italy were retrospectively reviewed. All cases with a main pathological diagnosis of PanNET were excluded. Results: An incidental associated diagnosis of PanNET was made in 41 specimens (4%). Among those 41 cases, 29 (71%) had a largest diameter < 5 mm (microadenoma), whereas the other 12 (29%) had a maximum size .5 mm (median diameter of the whole series = 3 mm, range 1.15). The association with a main diagnosis of intra intraductal papillary mucinous neoplasms (IPMN) was significantly higher for patients who had an incidental PanNET (p = 0.048). There was no association between incidental diagnosis of PanNET and age, gender, BMI, smoking habit, diabetes, and type of operation. Conclusions: The frequency of incidental histological diagnosis of PanNET is considerably high, suggesting that their real prevalence is probably underestimated. The present study suggests a possible correlation between the incidental occurrence of PanNET and IPMN.

Original languageEnglish
Pages (from-to)165-170
Number of pages6
JournalNeuroendocrinology
Volume109
Issue number2
DOIs
Publication statusPublished - Aug 1 2019

Keywords

  • Histology
  • Incidental diagnosis
  • Pancreatic neuroendocrine tumor

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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