TY - JOUR
T1 - Is the Real Prevalence of Pancreatic Neuroendocrine Tumors Underestimated? A Retrospective Study on a Large Series of Pancreatic Specimens
AU - Partelli, Stefano
AU - Giannone, Fabio
AU - Schiavo Lena, Marco
AU - Muffatti, Francesca
AU - Andreasi, Valentina
AU - Crippa, Stefano
AU - Tamburrino, Domenico
AU - Zamboni, Giuseppe
AU - Rubini, Corrado
AU - Doglioni, Claudio
AU - Falconi, Massimo
PY - 2019/8/1
Y1 - 2019/8/1
N2 - Background/Aims: The annual incidence of pancreatic neuroendocrine tumors (PanNET) has been estimated to be around 0.8/100,000 inhabitants. The aim of this study was to determine the frequency of incidental histological diagnosis of PanNET in pancreatic specimen evaluation for a purpose other other than PanNET diagnosis. Methods: One thousand seventy-four histopathological examinations of pancreatic specimens performed in 3 centers in Italy were retrospectively reviewed. All cases with a main pathological diagnosis of PanNET were excluded. Results: An incidental associated diagnosis of PanNET was made in 41 specimens (4%). Among those 41 cases, 29 (71%) had a largest diameter < 5 mm (microadenoma), whereas the other 12 (29%) had a maximum size .5 mm (median diameter of the whole series = 3 mm, range 1.15). The association with a main diagnosis of intra intraductal papillary mucinous neoplasms (IPMN) was significantly higher for patients who had an incidental PanNET (p = 0.048). There was no association between incidental diagnosis of PanNET and age, gender, BMI, smoking habit, diabetes, and type of operation. Conclusions: The frequency of incidental histological diagnosis of PanNET is considerably high, suggesting that their real prevalence is probably underestimated. The present study suggests a possible correlation between the incidental occurrence of PanNET and IPMN.
AB - Background/Aims: The annual incidence of pancreatic neuroendocrine tumors (PanNET) has been estimated to be around 0.8/100,000 inhabitants. The aim of this study was to determine the frequency of incidental histological diagnosis of PanNET in pancreatic specimen evaluation for a purpose other other than PanNET diagnosis. Methods: One thousand seventy-four histopathological examinations of pancreatic specimens performed in 3 centers in Italy were retrospectively reviewed. All cases with a main pathological diagnosis of PanNET were excluded. Results: An incidental associated diagnosis of PanNET was made in 41 specimens (4%). Among those 41 cases, 29 (71%) had a largest diameter < 5 mm (microadenoma), whereas the other 12 (29%) had a maximum size .5 mm (median diameter of the whole series = 3 mm, range 1.15). The association with a main diagnosis of intra intraductal papillary mucinous neoplasms (IPMN) was significantly higher for patients who had an incidental PanNET (p = 0.048). There was no association between incidental diagnosis of PanNET and age, gender, BMI, smoking habit, diabetes, and type of operation. Conclusions: The frequency of incidental histological diagnosis of PanNET is considerably high, suggesting that their real prevalence is probably underestimated. The present study suggests a possible correlation between the incidental occurrence of PanNET and IPMN.
KW - Histology
KW - Incidental diagnosis
KW - Pancreatic neuroendocrine tumor
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U2 - 10.1159/000499606
DO - 10.1159/000499606
M3 - Article
C2 - 31117106
AN - SCOPUS:85066881090
VL - 109
SP - 165
EP - 170
JO - Neuroendocrinology
JF - Neuroendocrinology
SN - 0028-3835
IS - 2
ER -