Is the 13C-acetate breath test a valid procedure to analyse gastric emptying in children?

C. Gatti, F. Federici Di Abriola, L. Dall'Oglio, M. Villa, F. Franchini, S. Amarri

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Background/Purpose: Scintigraphy is regarded as the 'gold standard' procedure in measuring gastric emptying (GE) rates. 13C-acetate breath test (ABT), which already has been validated in adults, is a noninvasive and nonradioactive alternative method. The aim of the current study was to validate ABT against technetium Tc 99m scintigraphy in children affected by delayed GE. Methods: Sixty children were recruited and divided into 2 groups: group A, 30 healthy controls; group B, 30 patients with gastroesophageal reflux, and scintigraphy-documented DGE (15 neurologically impaired). After an overnight fast, all of them underwent ABT using 25 to 150 mg 13C- acetate. Breath samples were obtained at baseline and then every 10 minutes for 2 hours. The 13CO2 to 12CO2 ratio in breath samples was analysed by isotope ratio mass spectrometry. Data are expressed as follows: time of peak 13C exhalation (tP13CO(2b)) and half emptying time in ABT (t(1/2b)), and scintigraphy half emptying time (t(1/2s)). Results: In controls tP13CO(2b) was 37 ± 13 minutes and t(1/2b) 74 ± 12 minutes. In patients tP13CO(2b) and t(1/2b) were, respectively, 65 ± 26 minutes and 104 ± 18 minutes t(1/2s) was 91 ± 21 minutes. In group B tP13CO(2b) and t(1/2b) were delayed significantly compared with controls, respectively, P <.03 and P <.01. In group B significant correlation between t(1/2s) and t(1/2b) was noted (r1 = 0.97). A close correlation was also observed between t(1/2s) and tP13CO(2b) (r2 = 0.95). Conclusion: The 13C ABT is an easy, reliable, and less expensive procedure for measuring GE, and its results closely correlate with those of scintigraphy in a paediatric population.

Original languageEnglish
Pages (from-to)62-65
Number of pages4
JournalJournal of Pediatric Surgery
Volume35
Issue number1
Publication statusPublished - 2000

Fingerprint

Breath Tests
Gastric Emptying
Acetates
Radionuclide Imaging
Exhalation
Technetium
Gastroesophageal Reflux
Isotopes
Mass Spectrometry
Pediatrics
Population

Keywords

  • C
  • Breath test
  • Delayed gastric emptying
  • Gastric scintigraphy
  • Gastroesophageal reflux

ASJC Scopus subject areas

  • Surgery

Cite this

Gatti, C., Federici Di Abriola, F., Dall'Oglio, L., Villa, M., Franchini, F., & Amarri, S. (2000). Is the 13C-acetate breath test a valid procedure to analyse gastric emptying in children? Journal of Pediatric Surgery, 35(1), 62-65.

Is the 13C-acetate breath test a valid procedure to analyse gastric emptying in children? / Gatti, C.; Federici Di Abriola, F.; Dall'Oglio, L.; Villa, M.; Franchini, F.; Amarri, S.

In: Journal of Pediatric Surgery, Vol. 35, No. 1, 2000, p. 62-65.

Research output: Contribution to journalArticle

Gatti, C, Federici Di Abriola, F, Dall'Oglio, L, Villa, M, Franchini, F & Amarri, S 2000, 'Is the 13C-acetate breath test a valid procedure to analyse gastric emptying in children?', Journal of Pediatric Surgery, vol. 35, no. 1, pp. 62-65.
Gatti, C. ; Federici Di Abriola, F. ; Dall'Oglio, L. ; Villa, M. ; Franchini, F. ; Amarri, S. / Is the 13C-acetate breath test a valid procedure to analyse gastric emptying in children?. In: Journal of Pediatric Surgery. 2000 ; Vol. 35, No. 1. pp. 62-65.
@article{16166a9cf9fb42c987787e38c76429b2,
title = "Is the 13C-acetate breath test a valid procedure to analyse gastric emptying in children?",
abstract = "Background/Purpose: Scintigraphy is regarded as the 'gold standard' procedure in measuring gastric emptying (GE) rates. 13C-acetate breath test (ABT), which already has been validated in adults, is a noninvasive and nonradioactive alternative method. The aim of the current study was to validate ABT against technetium Tc 99m scintigraphy in children affected by delayed GE. Methods: Sixty children were recruited and divided into 2 groups: group A, 30 healthy controls; group B, 30 patients with gastroesophageal reflux, and scintigraphy-documented DGE (15 neurologically impaired). After an overnight fast, all of them underwent ABT using 25 to 150 mg 13C- acetate. Breath samples were obtained at baseline and then every 10 minutes for 2 hours. The 13CO2 to 12CO2 ratio in breath samples was analysed by isotope ratio mass spectrometry. Data are expressed as follows: time of peak 13C exhalation (tP13CO(2b)) and half emptying time in ABT (t(1/2b)), and scintigraphy half emptying time (t(1/2s)). Results: In controls tP13CO(2b) was 37 ± 13 minutes and t(1/2b) 74 ± 12 minutes. In patients tP13CO(2b) and t(1/2b) were, respectively, 65 ± 26 minutes and 104 ± 18 minutes t(1/2s) was 91 ± 21 minutes. In group B tP13CO(2b) and t(1/2b) were delayed significantly compared with controls, respectively, P <.03 and P <.01. In group B significant correlation between t(1/2s) and t(1/2b) was noted (r1 = 0.97). A close correlation was also observed between t(1/2s) and tP13CO(2b) (r2 = 0.95). Conclusion: The 13C ABT is an easy, reliable, and less expensive procedure for measuring GE, and its results closely correlate with those of scintigraphy in a paediatric population.",
keywords = "C, Breath test, Delayed gastric emptying, Gastric scintigraphy, Gastroesophageal reflux",
author = "C. Gatti and {Federici Di Abriola}, F. and L. Dall'Oglio and M. Villa and F. Franchini and S. Amarri",
year = "2000",
language = "English",
volume = "35",
pages = "62--65",
journal = "Journal of Pediatric Surgery",
issn = "0022-3468",
publisher = "W.B. Saunders Ltd",
number = "1",

}

TY - JOUR

T1 - Is the 13C-acetate breath test a valid procedure to analyse gastric emptying in children?

AU - Gatti, C.

AU - Federici Di Abriola, F.

AU - Dall'Oglio, L.

AU - Villa, M.

AU - Franchini, F.

AU - Amarri, S.

PY - 2000

Y1 - 2000

N2 - Background/Purpose: Scintigraphy is regarded as the 'gold standard' procedure in measuring gastric emptying (GE) rates. 13C-acetate breath test (ABT), which already has been validated in adults, is a noninvasive and nonradioactive alternative method. The aim of the current study was to validate ABT against technetium Tc 99m scintigraphy in children affected by delayed GE. Methods: Sixty children were recruited and divided into 2 groups: group A, 30 healthy controls; group B, 30 patients with gastroesophageal reflux, and scintigraphy-documented DGE (15 neurologically impaired). After an overnight fast, all of them underwent ABT using 25 to 150 mg 13C- acetate. Breath samples were obtained at baseline and then every 10 minutes for 2 hours. The 13CO2 to 12CO2 ratio in breath samples was analysed by isotope ratio mass spectrometry. Data are expressed as follows: time of peak 13C exhalation (tP13CO(2b)) and half emptying time in ABT (t(1/2b)), and scintigraphy half emptying time (t(1/2s)). Results: In controls tP13CO(2b) was 37 ± 13 minutes and t(1/2b) 74 ± 12 minutes. In patients tP13CO(2b) and t(1/2b) were, respectively, 65 ± 26 minutes and 104 ± 18 minutes t(1/2s) was 91 ± 21 minutes. In group B tP13CO(2b) and t(1/2b) were delayed significantly compared with controls, respectively, P <.03 and P <.01. In group B significant correlation between t(1/2s) and t(1/2b) was noted (r1 = 0.97). A close correlation was also observed between t(1/2s) and tP13CO(2b) (r2 = 0.95). Conclusion: The 13C ABT is an easy, reliable, and less expensive procedure for measuring GE, and its results closely correlate with those of scintigraphy in a paediatric population.

AB - Background/Purpose: Scintigraphy is regarded as the 'gold standard' procedure in measuring gastric emptying (GE) rates. 13C-acetate breath test (ABT), which already has been validated in adults, is a noninvasive and nonradioactive alternative method. The aim of the current study was to validate ABT against technetium Tc 99m scintigraphy in children affected by delayed GE. Methods: Sixty children were recruited and divided into 2 groups: group A, 30 healthy controls; group B, 30 patients with gastroesophageal reflux, and scintigraphy-documented DGE (15 neurologically impaired). After an overnight fast, all of them underwent ABT using 25 to 150 mg 13C- acetate. Breath samples were obtained at baseline and then every 10 minutes for 2 hours. The 13CO2 to 12CO2 ratio in breath samples was analysed by isotope ratio mass spectrometry. Data are expressed as follows: time of peak 13C exhalation (tP13CO(2b)) and half emptying time in ABT (t(1/2b)), and scintigraphy half emptying time (t(1/2s)). Results: In controls tP13CO(2b) was 37 ± 13 minutes and t(1/2b) 74 ± 12 minutes. In patients tP13CO(2b) and t(1/2b) were, respectively, 65 ± 26 minutes and 104 ± 18 minutes t(1/2s) was 91 ± 21 minutes. In group B tP13CO(2b) and t(1/2b) were delayed significantly compared with controls, respectively, P <.03 and P <.01. In group B significant correlation between t(1/2s) and t(1/2b) was noted (r1 = 0.97). A close correlation was also observed between t(1/2s) and tP13CO(2b) (r2 = 0.95). Conclusion: The 13C ABT is an easy, reliable, and less expensive procedure for measuring GE, and its results closely correlate with those of scintigraphy in a paediatric population.

KW - C

KW - Breath test

KW - Delayed gastric emptying

KW - Gastric scintigraphy

KW - Gastroesophageal reflux

UR - http://www.scopus.com/inward/record.url?scp=0033628735&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033628735&partnerID=8YFLogxK

M3 - Article

C2 - 10646776

AN - SCOPUS:0033628735

VL - 35

SP - 62

EP - 65

JO - Journal of Pediatric Surgery

JF - Journal of Pediatric Surgery

SN - 0022-3468

IS - 1

ER -