Is the sympathetic nervous system altered in children with familial history of arterial hypertension?

L. A. Ferrara, T. S. Moscato, N. Pisanti, T. Marotta, V. Krogh, D. Capone, M. Mancini

Research output: Contribution to journalArticlepeer-review

Abstract

The sympathetic nervous system has been investigated in 42 children with family history of arterial hypertension and 68 children of the same age without hypertensive relatives. Pressure responses to mental arithmetic and to isometric handgrip stress were measured in both groups, along with 24 h catecholamine excretion. Resting blood pressure and heart rate did not show any difference between groups. The increase in diastolic pressure during the mental arithmetic exercise was, however, significantly greater in children with family history of hypertension. A sharp increase in blood pressure and heart rate was observed during isometric handgrip in both groups without any significant difference. Twenty-four hour catecholamine urinary excretion was significantly higher in the group with family history of hypertension (31 ± 15 vs. 23 ± 13 μg/24 h; p <0.05). These results seem to indicate that an initial impairment of the sympathetic activity is already detectable in young offspring of hypertensive patients.

Original languageEnglish
Pages (from-to)200-205
Number of pages6
JournalCardiology
Volume75
Issue number3
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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