Is there a case for PAF antagonists in the treatment of ischemie states?

Pierre Braquet, Monique Paubert-Braquet, Matyas Koltai, René Bourgain, Federico Bussolino, David Hosford

Research output: Contribution to journalArticle

Abstract

It is becoming clear that PAF plays an important role m a variety of life-threatening pathologies including shock, asthma, graft rejection and ischemia-induced damage. Pierre Braquet and colleagues analyse recent reports on PAF and ischemia and propose a hypothesis based on the catastrophe theory to explain why PAF antagonists are effective in countering ischemic injury and many other disorders. PAF antagonists, perhaps in combination with other agents, may consequently prove to have extensive therapeutic potential.

Original languageEnglish
Pages (from-to)23-30
Number of pages8
JournalTrends in Pharmacological Sciences
Volume10
Issue number1
DOIs
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

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