Is there a crossroad between infections, genetics, and Henoch-Schönlein purpura?

Donato Rigante, Luca Castellazzi, Annalisa Bosco, Susanna Esposito

Research output: Contribution to journalArticlepeer-review

Abstract

Henoch-Schönlein purpura is the most common systemic vasculitis in childhood, characterized by the presence of immunoglobulin A deposits in the small vessels of skin, gastrointestinal tube, joints and kidneys. Although there have been great efforts made in elucidating its pathogenic mechanisms, Henoch-Schönlein purpura etiology remains unknown: the basic scene comes across an abnormal inflammatory process deriving from immune reactions to various antigenic stimuli, which might be bacterial, viral, or parasitic agents, in a genetically prone individual. Then, a peculiar immune complex deposition in the vascular walls and overproduction of different proinflammatory molecules elicit different clinical signs, which might be differentiated according to either a specific trigger or a specific genetic make-up. The aim of this review is to make a critical appraisal of the last 15. years' medical literature concerning the relationship between infections, genetics, and Henoch-Schönlein purpura in pediatrics.

Original languageEnglish
Pages (from-to)1016-1021
Number of pages6
JournalAutoimmunity Reviews
Volume12
Issue number10
DOIs
Publication statusPublished - Aug 2013

Keywords

  • Child
  • Genetics
  • Henoch-Schönlein purpura
  • Infection

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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