Is there a link between the qualitative descriptors and the quantitative perception of dyspnea in asthma?

Claudia Coli, Monica Picariello, Loredana Stendardi, Michela Grazzini, Barbara Binazzi, Roberto Duranti, Giorgio Scano

Research output: Contribution to journalArticle

Abstract

Background: There is no obvious link between qualitative descriptors and overall intensity of dyspnea during bronchoconstriction in patients with asthma. Aims: To determine whether qualitative and quantitative perception of methacholine-induced bronchoconstriction independently contribute to characterizing clinically stable asthma. Material and methods: We assessed changes in inspiratory capacity, and quantitative (by Borg scale) and qualitative (by a panel of eight dyspnea descriptors) sensations of dyspnea at 20 to 30% fall in FEV 1 during methacholine inhalation in 49 asthmatics. Furthermore, we calculated the level of perception of bronchoconstriction at 20% fall in FEV 1 (PB 20). Results: Descriptors selected by patients during methacholine inhalation allowed us to define three language subgroups: (1) chest tightness (subgroup A, n = 21); (2) work/effort (subgroup B, n = 7); and (3) both descriptors (subgroup C, n = 13). Eight of the 49 patients (subgroup D) were not able to make a clear-cut distinction among descriptors. The subgroups exhibited similar function at baseline and during methacholine inhalation. Most importantly, patients selected chest tightness to a greater extent (42.85%), and work/effort (14.3%) and both descriptors (26.5%) to a lesser extent at the lowest level of bronchoconstriction (FEV 1 fall <10%) as at 20% fall in FEV 1. Thirty-two patients were normoperceivers (PB 20 ≥ 1.4 to <5 arbitrary units [au]), 7 patients were hyperperceivers (PB 20 ≥ 5 au), and 10 patients were hypoperceivers (PB 20 <1.4 au). Language subgroups were equally distributed across the perceiver subgroups. Conclusions: In patients with clinically stable asthma, PB 20 and language of dyspnea independently contribute to defining the condition of the disease. However, the possibility that this independence may be due to a β-error should be taken into account.

Original languageEnglish
Pages (from-to)436-441
Number of pages6
JournalChest
Volume130
Issue number2
DOIs
Publication statusPublished - Aug 2006

    Fingerprint

Keywords

  • Bronchoconstriction
  • Chest tightness
  • Dyspnea
  • Respiratory work/effort

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Coli, C., Picariello, M., Stendardi, L., Grazzini, M., Binazzi, B., Duranti, R., & Scano, G. (2006). Is there a link between the qualitative descriptors and the quantitative perception of dyspnea in asthma? Chest, 130(2), 436-441. https://doi.org/10.1378/chest.130.2.436