Is there a long-lasting effect of a short-term nerve growth factor application on axotomized rat septohippocampal neurons?

T. Naumann, P. Kermer, V. Seydewitz, R. Ortmann, F. D'Amato, M. Frotscher

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Loss of choline acetyltransferase (ChAT)-immunoreactive neurons in the medial septum (MS) following fimbria transection can be prevented by nerve growth factor (NGF) application. Here we have studied the long-term effects of a short-term NGF treatment starting immediately after lesion and lasting for the first 3 weeks. We demonstrate that this NGF treatment rescues many ChAT neurons after short survival time (3 weeks) but does not have a long-lasting (6 months) effect on both ChAT- and parvalbumin-immunopositive (GABAergic) MS neurons.

Original languageEnglish
Pages (from-to)213-215
Number of pages3
JournalNeuroscience Letters
Volume173
Issue number1-2
DOIs
Publication statusPublished - May 23 1994

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Choline O-Acetyltransferase
Nerve Growth Factor
Neurons
Parvalbumins

Keywords

  • Cholinergic neuron
  • Fimbria-fornix transection
  • Medial septal nucleus
  • Neuronal survival
  • Neurotrophin
  • Parvalbumin

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Is there a long-lasting effect of a short-term nerve growth factor application on axotomized rat septohippocampal neurons? / Naumann, T.; Kermer, P.; Seydewitz, V.; Ortmann, R.; D'Amato, F.; Frotscher, M.

In: Neuroscience Letters, Vol. 173, No. 1-2, 23.05.1994, p. 213-215.

Research output: Contribution to journalArticle

Naumann, T. ; Kermer, P. ; Seydewitz, V. ; Ortmann, R. ; D'Amato, F. ; Frotscher, M. / Is there a long-lasting effect of a short-term nerve growth factor application on axotomized rat septohippocampal neurons?. In: Neuroscience Letters. 1994 ; Vol. 173, No. 1-2. pp. 213-215.
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