Is there a long-lasting effect of a short-term nerve growth factor application on axotomized rat septohippocampal neurons?

T. Naumann, P. Kermer, V. Seydewitz, R. Ortmann, F. D'Amato, M. Frotscher

Research output: Contribution to journalArticlepeer-review

Abstract

Loss of choline acetyltransferase (ChAT)-immunoreactive neurons in the medial septum (MS) following fimbria transection can be prevented by nerve growth factor (NGF) application. Here we have studied the long-term effects of a short-term NGF treatment starting immediately after lesion and lasting for the first 3 weeks. We demonstrate that this NGF treatment rescues many ChAT neurons after short survival time (3 weeks) but does not have a long-lasting (6 months) effect on both ChAT- and parvalbumin-immunopositive (GABAergic) MS neurons.

Original languageEnglish
Pages (from-to)213-215
Number of pages3
JournalNeuroscience Letters
Volume173
Issue number1-2
DOIs
Publication statusPublished - May 23 1994

Keywords

  • Cholinergic neuron
  • Fimbria-fornix transection
  • Medial septal nucleus
  • Neuronal survival
  • Neurotrophin
  • Parvalbumin

ASJC Scopus subject areas

  • Neuroscience(all)

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