Is there a rationale for pulmonary rehabilitation following successful chemotherapy for tuberculosis?

Marcela Muñoz-Torrico, Adrian Rendon, Rosella Centis, Lia D’Ambrosio, Zhenia Fuentes, Carlos Torres-Duque, Fernanda Mello, Margareth Dalcolmo, Rogelio Pérez-Padilla, Antonio Spanevello, Giovanni Battista Migliori

Research output: Contribution to journalReview article

Abstract

The role of tuberculosis as a public health care priority and the availability of diagnostic tools to evaluate functional status (spirometry, plethysmography, and DLCO determination), arterial blood gases, capacity to perform exercise, lesions (chest X-ray and CT), and quality of life justify the effort to consider what needs to be done when patients have completed their treatment. To our knowledge, no review has ever evaluated this topic in a comprehensive manner. Our objective was to review the available evidence on this topic and draw conclusions regarding the future role of the “post-tuberculosis treatment” phase, which will potentially affect several million cases every year. We carried out a non-systematic literature review based on a PubMed search using specific keywords (various combinations of the terms “tuberculosis”, “rehabilitation”, “multidrug-resistant tuberculosis”, “pulmonary disease”, “obstructive lung disease”, and “lung volume measurements”). The reference lists of the most important studies were retrieved in order to improve the sensitivity of the search. Manuscripts written in English, Spanish, and Russian were selected. The main areas of interest were tuberculosis sequelae following tuberculosis diagnosis and treatment; “destroyed lung”; functional evaluation of sequelae; pulmonary rehabilitation interventions (physiotherapy, long-term oxygen therapy, and ventilation); and multidrug-resistant tuberculosis. The evidence found suggests that tuberculosis is definitively responsible for functional sequelae, primarily causing an obstructive pattern on spirometry (but also restrictive and mixed patterns), and that there is a rationale for pulmonary rehabilitation. We also provide a list of variables that should be discussed in future studies on pulmonary rehabilitation in patients with post-tuberculosis sequelae.

Original languageEnglish
Pages (from-to)374-385
Number of pages12
JournalJornal Brasileiro de Pneumologia
Volume42
Issue number5
DOIs
Publication statusPublished - Sep 1 2016

Keywords

  • Diagnostic imaging
  • Quality of life
  • Respiratory function tests
  • Tuberculosis/complications
  • Tuberculosis/rehabilitation
  • Tuberculosis/therapy

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Fingerprint Dive into the research topics of 'Is there a rationale for pulmonary rehabilitation following successful chemotherapy for tuberculosis?'. Together they form a unique fingerprint.

  • Cite this

    Muñoz-Torrico, M., Rendon, A., Centis, R., D’Ambrosio, L., Fuentes, Z., Torres-Duque, C., Mello, F., Dalcolmo, M., Pérez-Padilla, R., Spanevello, A., & Migliori, G. B. (2016). Is there a rationale for pulmonary rehabilitation following successful chemotherapy for tuberculosis? Jornal Brasileiro de Pneumologia, 42(5), 374-385. https://doi.org/10.1590/S1806-37562016000000226