Is there a relationship between high C-reactive protein (CRP) levels and dementia?

A. Mancinella, M. Mancinella, G. Carpinteri, A. Bellomo, C. Fossati, V. Gianturco, A. Iori, E. Ettorre, G. Troisi, V. Marigliano

Research output: Contribution to journalArticle

Abstract

Inflammation is believed to play a pivotal role in dementia, but its role is still unclear. The aim of our study was to analyze the interplay among markers of inflammation, such as fibrinogen and high CRP levels, and dementia. First, we performed a cross-sectional study comparing markers of inflammation between 99 patients affected by dementia (mean age: 83.0+/-0.6 years) and 99 controls (mean age: 83.9+/-0.7 years). Then, we analyzed the relationship between inflammation and dementia in the same population composed by 34 Alzheimer's disease (AD) patients (mean age: 83.4+/-0.8 years), 64 vascular dementia (VaD) patients (mean age: 82.7+0.8 years) and 99 controls. Patients affected by dementia had higher CRP levels than controls (2.6+/-+/-0.2 vs. 0.7 + 0.1 p <0.001, respectively). AD patients had higher CRP levels than VaD patients (4.2 + 0.6 vs. 1.7+/-0.2, p <0.001, respectively). Stepwise multiple logistic regression analysis showed that dementia (odds ratio=OR=4.965, 95% confidence interval=Cl=1.402-13.23, p=0.004), fibrinogen (OR=1.011, Cl=1.007-1.015, p

Original languageEnglish
Pages (from-to)185-194
Number of pages10
JournalArchives of Gerontology and Geriatrics
Volume49 Suppl 1
Publication statusPublished - 2009

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ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology
  • Health(social science)
  • Gerontology

Cite this

Mancinella, A., Mancinella, M., Carpinteri, G., Bellomo, A., Fossati, C., Gianturco, V., Iori, A., Ettorre, E., Troisi, G., & Marigliano, V. (2009). Is there a relationship between high C-reactive protein (CRP) levels and dementia? Archives of Gerontology and Geriatrics, 49 Suppl 1, 185-194.