TY - JOUR
T1 - Is there a relationship between right-ventricular and right atrial mechanics and functional capacity in hypertensive patients?
AU - Tadic, Marijana
AU - Cuspidi, Cesare
AU - Suzic-Lazic, Jelena
AU - Andric, Anita
AU - Stojcevski, Biljana
AU - Ivanovic, Branislava
AU - Hot, Senada
AU - Scepanovic, Radisav
AU - Celic, Vera
PY - 2014
Y1 - 2014
N2 - BACKGROUND:: We sought to assess right-ventricular and right atrial deformation in patients with arterial hypertension by two-dimensional speckle tracking imaging and three-dimensional echocardiography (3DE), and define the relationship between right-ventricular mechanics and exercise capacity in the study population. METHODS:: This cross-sectional study included recently diagnosed untreated hypertensive patients, well controlled hypertensive patients, treated patients with unsatisfactory controlled blood pressure and control individuals adjusted by sex and age. All the patients underwent complete two-dimensional echocardiography and 3DE examination, as well as cardiopulmonary exercise testing. RESULTS:: Right-ventricular strain, and systolic and early diastolic strain rates were significantly decreased in the untreated and the uncontrolled hypertensive patients in comparison with the controls and the well controlled participants. Similar results were obtained for right atrial strain and strain rates. 3DE right-ventricular volumes were increased, whereas 3DE right-ventricular ejection fraction was decreased in the uncontrolled hypertensive patients in comparison with the controls and the well treated patients. Differences in 3DE right-ventricular volumes disappeared after adjustment for body surface area. Considering the whole study population, global right-ventricular strain (β=0.29, P=0.018) and 3D right-ventricular stroke volume (β=0.22, P=0.041) were independently associated with peak oxygen uptake (VO2 max) which was significantly decreased in the untreated and the uncontrolled hypertensive patients in comparison with the remaining two groups. CONCLUSION:: Our study showed that right-ventricular and right atrial mechanics, as well as exercise capacity, are significantly deteriorated in the hypertensive patients who are untreated or ineffectively treated. Global right-ventricular strain and 3DE right-ventricular stroke volume are independently associated with functional capacity in the whole study population.
AB - BACKGROUND:: We sought to assess right-ventricular and right atrial deformation in patients with arterial hypertension by two-dimensional speckle tracking imaging and three-dimensional echocardiography (3DE), and define the relationship between right-ventricular mechanics and exercise capacity in the study population. METHODS:: This cross-sectional study included recently diagnosed untreated hypertensive patients, well controlled hypertensive patients, treated patients with unsatisfactory controlled blood pressure and control individuals adjusted by sex and age. All the patients underwent complete two-dimensional echocardiography and 3DE examination, as well as cardiopulmonary exercise testing. RESULTS:: Right-ventricular strain, and systolic and early diastolic strain rates were significantly decreased in the untreated and the uncontrolled hypertensive patients in comparison with the controls and the well controlled participants. Similar results were obtained for right atrial strain and strain rates. 3DE right-ventricular volumes were increased, whereas 3DE right-ventricular ejection fraction was decreased in the uncontrolled hypertensive patients in comparison with the controls and the well treated patients. Differences in 3DE right-ventricular volumes disappeared after adjustment for body surface area. Considering the whole study population, global right-ventricular strain (β=0.29, P=0.018) and 3D right-ventricular stroke volume (β=0.22, P=0.041) were independently associated with peak oxygen uptake (VO2 max) which was significantly decreased in the untreated and the uncontrolled hypertensive patients in comparison with the remaining two groups. CONCLUSION:: Our study showed that right-ventricular and right atrial mechanics, as well as exercise capacity, are significantly deteriorated in the hypertensive patients who are untreated or ineffectively treated. Global right-ventricular strain and 3DE right-ventricular stroke volume are independently associated with functional capacity in the whole study population.
KW - Exercise capacity
KW - Hypertension
KW - Right ventricle
KW - Speckle tracking imaging
KW - Three-dimensional echocardiography
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U2 - 10.1097/HJH.0000000000000102
DO - 10.1097/HJH.0000000000000102
M3 - Article
C2 - 24434853
AN - SCOPUS:84896316938
VL - 32
SP - 929
EP - 937
JO - Journal of Hypertension
JF - Journal of Hypertension
SN - 0263-6352
IS - 4
ER -