Is There a Role for Genetics in the Prevention of Sudden Cardiac Death?

Alessandro Faragli, Katherine Underwood, Silvia G. Priori, Andrea Mazzanti

Research output: Contribution to journalReview articlepeer-review

Abstract

The identification of patients at risk for sudden cardiac death (SCD) is fundamental for both acquired cardiovascular diseases (such as coronary artery diseases, CAD) and inherited arrhythmia syndromes (such as the long-QT syndrome, LQTS). Genetics may play a role in both situations, although the potential to exploit this information to reduce the burden of SCD varies among these two groups. Concerning acquired cardiovascular diseases, which affect most of the general population, preliminary data suggest an association between genetics and the risk of dying suddenly. The maximal utility, instead, is reached in inherited arrhythmia syndromes, where the discovery of monogenic diseases such as LQTS tracked the way for the first genotype-phenotype correlations. The aim of this review is to provide a general overview focusing on the current genetic knowledge and on the present and future applicability for prevention in these two populations at risk for SCD.

Original languageEnglish
Pages (from-to)1124-1132
Number of pages9
JournalJournal of Cardiovascular Electrophysiology
Volume27
Issue number9
DOIs
Publication statusPublished - Sep 1 2016

Keywords

  • acquired cardiovascular diseases
  • genetic testing
  • inherited arrhythmia syndromes
  • preventive strategies
  • sudden cardiac death

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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