Is there a specific magnetic resonance phenotype characteristic of hereditary breast cancer?

Giovanna Trecate, Siranuosh Manoukian, Laura Suman, Daniele Vergnaghi, Monica Marchesini, Roberto Agresti, Cristina Ferraris, Bernard Peissel, Davide Scaramuzza, Silvana Bergonzi

Research output: Contribution to journal › Article

Abstract

Aims and background. The aim of the study was to investigate the growth rate of inherited breast cancer, to analyze its T2 signal intensity besides kinetic and morphologic aspects, and to verify whether there is any correlation between magnetic resonance imaging phenotype and BRCA status. Methods. Between June 2000 and September 2009, we enrolled 227 women at high genetic risk for breast cancer in a surveillance program, within a multicenter project of the Istituto Superiore di Sanità (Rome). Results. Thirty-four cancers were detected among 31 subjects. One patient refused magnetic resonance imaging because of claustrophobia. Compared with sporadic disease, hereditary cancer showed some differences, in terms of biologic attitude and semeiotic patterns. These differences were mainly registered for magnetic resonance imaging, where the most frequent radiological variant was represented by the very high T2 signal intensity (73%). Moreover, the size of 8 of the neoplasms showed a significant increase in less than one year, 5 of them in less than 6 months. Six lesions were in BRCA1 patients and the remaining in BRCA2. Furthermore, cancers with a high growth rate also demonstrated a significant increment in T2 signal intensity. Conclusions. Our results confirmed the high growth rate within BRCA-related breast cancers, especially for BRCA1 mutation carriers. In our experience, we found a specific imaging phenotype, represented by the high T2 signal intensity of hereditary breast cancer. To our knowledge, this is the first report that points out this new semeiotic parameter, which is usually typical of benign lesions. Considering the correlation between high growth rate and high T2 signal intensity, the former seems to be related to the absence of induction of a desmoplastic reaction that could somehow restrict cancer growth.

Original languageEnglish
Pages (from-to)363-384
Number of pages22
JournalTumori
Volume96
Issue number3
Publication statusPublished - May 2010

Fingerprint

Magnetic Resonance Spectroscopy
Breast Neoplasms
Phenotype
Growth
Magnetic Resonance Imaging
Neoplasms
Inborn Genetic Diseases
Phobic Disorders
Mutation

Keywords

  • BRCA mutation
  • Breast cancer
  • Growth rate
  • Magnetic resonance imaging
  • T2 signal intensity

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Is there a specific magnetic resonance phenotype characteristic of hereditary breast cancer? / Trecate, Giovanna; Manoukian, Siranuosh; Suman, Laura; Vergnaghi, Daniele; Marchesini, Monica; Agresti, Roberto; Ferraris, Cristina; Peissel, Bernard; Scaramuzza, Davide; Bergonzi, Silvana.

In: Tumori, Vol. 96, No. 3, 05.2010, p. 363-384.

Research output: Contribution to journal › Article

Trecate, G, Manoukian, S, Suman, L, Vergnaghi, D, Marchesini, M, Agresti, R, Ferraris, C, Peissel, B, Scaramuzza, D & Bergonzi, S 2010, 'Is there a specific magnetic resonance phenotype characteristic of hereditary breast cancer?', Tumori, vol. 96, no. 3, pp. 363-384.
Trecate G, Manoukian S, Suman L, Vergnaghi D, Marchesini M, Agresti R et al. Is there a specific magnetic resonance phenotype characteristic of hereditary breast cancer? Tumori. 2010 May;96(3):363-384.
Trecate, Giovanna ; Manoukian, Siranuosh ; Suman, Laura ; Vergnaghi, Daniele ; Marchesini, Monica ; Agresti, Roberto ; Ferraris, Cristina ; Peissel, Bernard ; Scaramuzza, Davide ; Bergonzi, Silvana. / Is there a specific magnetic resonance phenotype characteristic of hereditary breast cancer?. In: Tumori. 2010 ; Vol. 96, No. 3. pp. 363-384.
@article{da89a4de1786447bbe41ccc5e2c97f5f,
title = "Is there a specific magnetic resonance phenotype characteristic of hereditary breast cancer?",
abstract = "Aims and background. The aim of the study was to investigate the growth rate of inherited breast cancer, to analyze its T2 signal intensity besides kinetic and morphologic aspects, and to verify whether there is any correlation between magnetic resonance imaging phenotype and BRCA status. Methods. Between June 2000 and September 2009, we enrolled 227 women at high genetic risk for breast cancer in a surveillance program, within a multicenter project of the Istituto Superiore di Sanit{\`a} (Rome). Results. Thirty-four cancers were detected among 31 subjects. One patient refused magnetic resonance imaging because of claustrophobia. Compared with sporadic disease, hereditary cancer showed some differences, in terms of biologic attitude and semeiotic patterns. These differences were mainly registered for magnetic resonance imaging, where the most frequent radiological variant was represented by the very high T2 signal intensity (73{\%}). Moreover, the size of 8 of the neoplasms showed a significant increase in less than one year, 5 of them in less than 6 months. Six lesions were in BRCA1 patients and the remaining in BRCA2. Furthermore, cancers with a high growth rate also demonstrated a significant increment in T2 signal intensity. Conclusions. Our results confirmed the high growth rate within BRCA-related breast cancers, especially for BRCA1 mutation carriers. In our experience, we found a specific imaging phenotype, represented by the high T2 signal intensity of hereditary breast cancer. To our knowledge, this is the first report that points out this new semeiotic parameter, which is usually typical of benign lesions. Considering the correlation between high growth rate and high T2 signal intensity, the former seems to be related to the absence of induction of a desmoplastic reaction that could somehow restrict cancer growth.",
keywords = "BRCA mutation, Breast cancer, Growth rate, Magnetic resonance imaging, T2 signal intensity",
author = "Giovanna Trecate and Siranuosh Manoukian and Laura Suman and Daniele Vergnaghi and Monica Marchesini and Roberto Agresti and Cristina Ferraris and Bernard Peissel and Davide Scaramuzza and Silvana Bergonzi",
year = "2010",
month = "5",
language = "English",
volume = "96",
pages = "363--384",
journal = "Tumori",
issn = "0300-8916",
publisher = "SAGE Publications Ltd",
number = "3",

}

TY - JOUR

T1 - Is there a specific magnetic resonance phenotype characteristic of hereditary breast cancer?

AU - Trecate, Giovanna

AU - Manoukian, Siranuosh

AU - Suman, Laura

AU - Vergnaghi, Daniele

AU - Marchesini, Monica

AU - Agresti, Roberto

AU - Ferraris, Cristina

AU - Peissel, Bernard

AU - Scaramuzza, Davide

AU - Bergonzi, Silvana

PY - 2010/5

Y1 - 2010/5

N2 - Aims and background. The aim of the study was to investigate the growth rate of inherited breast cancer, to analyze its T2 signal intensity besides kinetic and morphologic aspects, and to verify whether there is any correlation between magnetic resonance imaging phenotype and BRCA status. Methods. Between June 2000 and September 2009, we enrolled 227 women at high genetic risk for breast cancer in a surveillance program, within a multicenter project of the Istituto Superiore di Sanità (Rome). Results. Thirty-four cancers were detected among 31 subjects. One patient refused magnetic resonance imaging because of claustrophobia. Compared with sporadic disease, hereditary cancer showed some differences, in terms of biologic attitude and semeiotic patterns. These differences were mainly registered for magnetic resonance imaging, where the most frequent radiological variant was represented by the very high T2 signal intensity (73%). Moreover, the size of 8 of the neoplasms showed a significant increase in less than one year, 5 of them in less than 6 months. Six lesions were in BRCA1 patients and the remaining in BRCA2. Furthermore, cancers with a high growth rate also demonstrated a significant increment in T2 signal intensity. Conclusions. Our results confirmed the high growth rate within BRCA-related breast cancers, especially for BRCA1 mutation carriers. In our experience, we found a specific imaging phenotype, represented by the high T2 signal intensity of hereditary breast cancer. To our knowledge, this is the first report that points out this new semeiotic parameter, which is usually typical of benign lesions. Considering the correlation between high growth rate and high T2 signal intensity, the former seems to be related to the absence of induction of a desmoplastic reaction that could somehow restrict cancer growth.

AB - Aims and background. The aim of the study was to investigate the growth rate of inherited breast cancer, to analyze its T2 signal intensity besides kinetic and morphologic aspects, and to verify whether there is any correlation between magnetic resonance imaging phenotype and BRCA status. Methods. Between June 2000 and September 2009, we enrolled 227 women at high genetic risk for breast cancer in a surveillance program, within a multicenter project of the Istituto Superiore di Sanità (Rome). Results. Thirty-four cancers were detected among 31 subjects. One patient refused magnetic resonance imaging because of claustrophobia. Compared with sporadic disease, hereditary cancer showed some differences, in terms of biologic attitude and semeiotic patterns. These differences were mainly registered for magnetic resonance imaging, where the most frequent radiological variant was represented by the very high T2 signal intensity (73%). Moreover, the size of 8 of the neoplasms showed a significant increase in less than one year, 5 of them in less than 6 months. Six lesions were in BRCA1 patients and the remaining in BRCA2. Furthermore, cancers with a high growth rate also demonstrated a significant increment in T2 signal intensity. Conclusions. Our results confirmed the high growth rate within BRCA-related breast cancers, especially for BRCA1 mutation carriers. In our experience, we found a specific imaging phenotype, represented by the high T2 signal intensity of hereditary breast cancer. To our knowledge, this is the first report that points out this new semeiotic parameter, which is usually typical of benign lesions. Considering the correlation between high growth rate and high T2 signal intensity, the former seems to be related to the absence of induction of a desmoplastic reaction that could somehow restrict cancer growth.

KW - BRCA mutation

KW - Breast cancer

KW - Growth rate

KW - Magnetic resonance imaging

KW - T2 signal intensity

UR - http://www.scopus.com/inward/record.url?scp=77954996146&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77954996146&partnerID=8YFLogxK

M3 - Article

C2 - 20845796

AN - SCOPUS:77954996146

VL - 96

SP - 363

EP - 384

JO - Tumori

JF - Tumori

SN - 0300-8916

IS - 3

ER -

Access to Document