Is there a standard chemotherapeutic regimen for hormone-refractory prostate cancer? Present and future approaches in the management of the disease

Giuseppe Di Lorenzo, Riccardo Autorino, Michele De Laurentiis, Roberto Bianco, Rossella Lauria, Antonio Giordano, Marco De Sio, Massimino D'Armiento, Angelo Raffaele Bianco, Sabino De Placido

Research output: Contribution to journalArticlepeer-review

Abstract

Prostate cancer that no longer responds to hormonal manipulation can be defined as hormone-refractory prostate cancer. Until recently, there has been no standard chemotherapeutic approach for hormone-refractory prostate cancer. The major benefits of chemotherapy in the treatment of the disease are palliative in nature, in terms of reduction of pain and use of analgesics and improvement of performance status, as followed in the most recent trials. Phase III studies are necessary to better evaluate the efficacy of the different regimens, because several old studies suffer for methodological deficits. There is a promising activity of new drug combinations, such as vinca alkaloids and taxanes. Phase I and II trial are testing combinations of classic chemotherapeutic agents and biologic drugs, and the first results appear interesting. In this article, recent advances in the treatment of hormone-refractory prostate cancer using chemotherapeutic regimens are critically reviewed.

Original languageEnglish
Pages (from-to)349-360
Number of pages12
JournalTumori
Volume89
Issue number4
Publication statusPublished - Jul 2003

Keywords

  • Chemotherapy
  • Hormone-refractory prostate cancer
  • Treatment

ASJC Scopus subject areas

  • Cancer Research

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