Abstract
Purpose of review Thalassemia is the most common form of inherited anemia, characterized by variable clinical phenotypes. The purpose of this review is to summarize the transfusion support in thalassemia patients and the management of transfusion-related iron overload. Recent findings The most recent evidence on transfusion strategy and iron chelation therapy in thalassemia arising from clinical trials as well as from recommendation guidelines are critically discussed. Summary Enhancements in the global care of thalassemia, resulting from the combination of an appropriate transfusion approach and iron chelation therapy, have produced a significant improvement in the quality of life and, finally, in the prognosis of patients affected by this inherited hematologic disorder.
| Original language | English |
|---|---|
| Pages (from-to) | 558-564 |
| Number of pages | 7 |
| Journal | Current Opinion in Hematology |
| Volume | 24 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Nov 1 2017 |
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Keywords
- iron chelation
- iron overload
- red blood cell transfusion
- thalassemia
ASJC Scopus subject areas
- Hematology
Cite this
Is there a standard-of-care for transfusion therapy in thalassemia? / Franchini, Massimo; Forni, Gian L.; Liumbruno, Giancarlo M.
In: Current Opinion in Hematology, Vol. 24, No. 6, 01.11.2017, p. 558-564.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Is there a standard-of-care for transfusion therapy in thalassemia?
AU - Franchini, Massimo
AU - Forni, Gian L.
AU - Liumbruno, Giancarlo M.
PY - 2017/11/1
Y1 - 2017/11/1
N2 - Purpose of review Thalassemia is the most common form of inherited anemia, characterized by variable clinical phenotypes. The purpose of this review is to summarize the transfusion support in thalassemia patients and the management of transfusion-related iron overload. Recent findings The most recent evidence on transfusion strategy and iron chelation therapy in thalassemia arising from clinical trials as well as from recommendation guidelines are critically discussed. Summary Enhancements in the global care of thalassemia, resulting from the combination of an appropriate transfusion approach and iron chelation therapy, have produced a significant improvement in the quality of life and, finally, in the prognosis of patients affected by this inherited hematologic disorder.
AB - Purpose of review Thalassemia is the most common form of inherited anemia, characterized by variable clinical phenotypes. The purpose of this review is to summarize the transfusion support in thalassemia patients and the management of transfusion-related iron overload. Recent findings The most recent evidence on transfusion strategy and iron chelation therapy in thalassemia arising from clinical trials as well as from recommendation guidelines are critically discussed. Summary Enhancements in the global care of thalassemia, resulting from the combination of an appropriate transfusion approach and iron chelation therapy, have produced a significant improvement in the quality of life and, finally, in the prognosis of patients affected by this inherited hematologic disorder.
KW - iron chelation
KW - iron overload
KW - red blood cell transfusion
KW - thalassemia
UR - http://www.scopus.com/inward/record.url?scp=85024487784&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85024487784&partnerID=8YFLogxK
U2 - 10.1097/MOH.0000000000000373
DO - 10.1097/MOH.0000000000000373
M3 - Review article
C2 - 28719386
AN - SCOPUS:85024487784
VL - 24
SP - 558
EP - 564
JO - Current Opinion in Hematology
JF - Current Opinion in Hematology
SN - 1065-6251
IS - 6
ER -