Is there a standard-of-care for transfusion therapy in thalassemia?

Massimo Franchini, Gian L. Forni, Giancarlo M. Liumbruno

Research output: Contribution to journalReview article

Abstract

Purpose of review Thalassemia is the most common form of inherited anemia, characterized by variable clinical phenotypes. The purpose of this review is to summarize the transfusion support in thalassemia patients and the management of transfusion-related iron overload. Recent findings The most recent evidence on transfusion strategy and iron chelation therapy in thalassemia arising from clinical trials as well as from recommendation guidelines are critically discussed. Summary Enhancements in the global care of thalassemia, resulting from the combination of an appropriate transfusion approach and iron chelation therapy, have produced a significant improvement in the quality of life and, finally, in the prognosis of patients affected by this inherited hematologic disorder.

Original languageEnglish
Pages (from-to)558-564
Number of pages7
JournalCurrent Opinion in Hematology
Volume24
Issue number6
DOIs
Publication statusPublished - Nov 1 2017

Keywords

  • iron chelation
  • iron overload
  • red blood cell transfusion
  • thalassemia

ASJC Scopus subject areas

  • Hematology

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