Is there an ‘ideal’ diet for patients with NAFLD?

Nicola Pugliese, Maria Corina Plaz Torres, Salvatore Petta, Luca Valenti, Edoardo G. Giannini, Alessio Aghemo

Research output: Contribution to journalReview articlepeer-review

Abstract

Nonalcoholic fatty liver disease (NAFLD) is a growing epidemic that encompasses three distinct clinical phenotypes: uncomplicated fatty liver, nonalcoholic steatohepatitis (NASH) and NASH-related cirrhosis with its complications, including hepatocellular carcinoma. To date, no pharmacological treatments have been approved and lifestyle modifications including reduced caloric intake targeting a 7%-10% weight loss from baseline assessment represent the standard approach. Mediterranean diet has been recommended as the best dietary pattern since it is easy to follow and, independently of caloric intake its nutritional components have beneficial metabolic effects that not only improve steatosis but also risk factors for cardiovascular events, the leading cause of morbidity/mortality in individuals with NAFLD. Other dietary patterns such as ketogenic diet and Dietary Approach to Stop Hypertension (DASH) diet can be used in patients with NAFLD. Recently, intermittent fasting diets have gained popularity among healthy individuals and have been proposed as a safe and effective treatment for the metabolic syndrome in experimental and in a few human studies. In this narrative review, we aim to summarize the evidence for the available dietary approaches for patients with NAFLD.

Original languageEnglish
JournalEuropean Journal of Clinical Investigation
DOIs
Publication statusAccepted/In press - 2021

Keywords

  • chronic liver disease
  • diet
  • dietary regimen
  • lifestyle intervention
  • nonalcoholic steatohepatitis

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry

Fingerprint

Dive into the research topics of 'Is there an ‘ideal’ diet for patients with NAFLD?'. Together they form a unique fingerprint.

Cite this