Is there an oligometastatic state in pancreatic cancer? Practical clinical considerations raise the question

Marta Scorsetti, Tiziana Comito, Davide Franceschini, Ciro Franzese, Maria Giuseppina Prete, Antonio D'Alessio, Silvia Bozzarelli, Lorenza Rimassa, Armando Santoro

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVES: To evaluate the role of stereotactic body radiotherapy (SBRT) as a local ablative treatment (LAT) in oligometastatic pancreatic cancer.

METHODS: Patients affected by histologically confirmed stage IV pancreatic adenocarcinoma were included in this analysis. Endpoints are local control (LC), progression-free survival (PFS), and overall survival (OS).

RESULTS: From 2013 to 2017, a total of 41 patients were treated with SBRT on 64 metastases. Most common sites of disease were lung (29.3%) and liver (56.1%). LC at 1 and 2 years were 88.9% (95% CI 73.2-98.6) and 73.9% (95% CI 50-87.5), respectively. Median LC was 39.9 months (95% CI 23.3-not reached).PFS rates at 1 and 2 years were 21.9% (95% CI 10.8-35.4) and 10.9% (95% CI 3.4-23.4), respectively. Median PFS was 5.4 months (95%CI 3.1-11.3).OS rates at 1 and 2 years were 79.9% (95% CI 63.7-89.4) and 46.7% (95% CI 29.6-62.2). Median OS was 23 months (95%CI 14.1-31.8).

CONCLUSIONS: Our results, although based on a retrospective analysis of a small number of patients, show that patients with oligometastatic pancreatic cancer may benefit from local treatment with SBRT. Larger studies are warranted to confirm these results.

ADVANCES IN KNOWLEDGE: Selected patients affected by oligometastatic pancreatic adenocarcinoma can benefit from local ablative approaches, like SBRT.

Original languageEnglish
Pages (from-to)20190627
JournalThe British journal of radiology
Volume93
Issue number1106
DOIs
Publication statusPublished - Feb 1 2020

Keywords

  • Adenocarcinoma/mortality
  • Aged
  • Aged, 80 and over
  • Disease Progression
  • Disease-Free Survival
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Neoplasm Metastasis
  • Pancreatic Neoplasms/mortality
  • Positron-Emission Tomography
  • Radiosurgery/methods
  • Retrospective Studies

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