Is thymosin action mediated by prostaglandin release?

C. Rinaldi Garaci, C. Favalli, V. Del Gobbo, E. Garaci, B. M. Jaffe

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Treatment of spleen cells derived from adult thymectomized mice with thymosin fraction 5 resulted in a rapid and dose-dependent stimulation of the release of immunoreactive prostaglandin E2. The release of prostaglandin E2 was associated with induction of theta antigen and was totally inhibited by indomethacin. In contrast, prostaglandin E2 release from spleen cells from intact donors was inhibited by treatment with fraction 5. The data support the concept that prostaglandin E2 mediates the effects of thymosin fraction 5 on lymphocytes.

Original languageEnglish
Pages (from-to)1163-1164
Number of pages2
JournalScience
Volume220
Issue number4602
DOIs
Publication statusPublished - 1983

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Thymosin
Dinoprostone
Prostaglandins
Spleen
Indomethacin
Lymphocytes
Antigens
thymosin fraction 5

ASJC Scopus subject areas

  • General

Cite this

Rinaldi Garaci, C., Favalli, C., Del Gobbo, V., Garaci, E., & Jaffe, B. M. (1983). Is thymosin action mediated by prostaglandin release? Science, 220(4602), 1163-1164. https://doi.org/10.1126/science.6574601

Is thymosin action mediated by prostaglandin release? / Rinaldi Garaci, C.; Favalli, C.; Del Gobbo, V.; Garaci, E.; Jaffe, B. M.

In: Science, Vol. 220, No. 4602, 1983, p. 1163-1164.

Research output: Contribution to journalArticle

Rinaldi Garaci, C, Favalli, C, Del Gobbo, V, Garaci, E & Jaffe, BM 1983, 'Is thymosin action mediated by prostaglandin release?', Science, vol. 220, no. 4602, pp. 1163-1164. https://doi.org/10.1126/science.6574601
Rinaldi Garaci C, Favalli C, Del Gobbo V, Garaci E, Jaffe BM. Is thymosin action mediated by prostaglandin release? Science. 1983;220(4602):1163-1164. https://doi.org/10.1126/science.6574601
Rinaldi Garaci, C. ; Favalli, C. ; Del Gobbo, V. ; Garaci, E. ; Jaffe, B. M. / Is thymosin action mediated by prostaglandin release?. In: Science. 1983 ; Vol. 220, No. 4602. pp. 1163-1164.
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