¿Es eficaz el tratamiento con hidroxicloroquina en el déficit de proteína C surfactante?

Translated title of the contribution: Is Treatment With Hydroxychloroquine Effective in Surfactant Protein C Deficiency?

Ingrid Rabach, Furio Poli, Floriana Zennaro, Claudio Germani, Alessandro Ventura, Egidio Barbi

Research output: Contribution to journalArticlepeer-review

Abstract

We present the case of two twin brothers with surfactant protein C deficiency who were treated with hydroxychloroquine for three years, with apparent success. The exact physiopathology of this disease is not known and there is no specific treatment for it. There is merely news from a few previous descriptions in the literature about the use of hydroxychloroquine for surfactant protein C deficiency with satisfactory results. Two years after the treatment was withdrawn, the twins were evaluated once again: they presented no new infections, growth and general state were normal and chest CT showed a notable additional reduction in the interstitial pneumopathy. These data seem to cast some doubt on the efficacy of hydroxychloroquine, and they suggest that the clinical improvement was simply the natural evolution of the disease.

Translated title of the contributionIs Treatment With Hydroxychloroquine Effective in Surfactant Protein C Deficiency?
Original languageSpanish
Pages (from-to)213-215
Number of pages3
JournalArchivos de Bronconeumologia
Volume49
Issue number5
DOIs
Publication statusPublished - May 2013

Keywords

  • Hydroxychloroquine
  • Juvenile interstitial lung disease
  • Respiratory distress syndrome
  • Surfactant protein C deficiency

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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