Is white-coat hypertension a risk factor for carotid atherosclerosis? A review and meta-analysis

Cesare Cuspidi; Carla Sala; Marijana Tadic; Marta Rescaldani; Guido Grassi; Giuseppe Mancia

doi:10.1097/MBP.0000000000000094

Is white-coat hypertension a risk factor for carotid atherosclerosis? A review and meta-analysis

Cesare Cuspidi, Carla Sala, Marijana Tadic, Marta Rescaldani, Guido Grassi, Giuseppe Mancia

Research output: Contribution to journal › Article › peer-review

Abstract

The association of white-coat hypertension (WCH) with target organ damage is still debated; in particular, the relationship of this blood pressure phenotype with subclinical vascular damage remains controversial. Thus, we carried out a systematic review and meta-analysis to provide updated information on carotid structural changes in WCH. Studies were identified using the following search terms: 'white coat hypertension', 'isolated clinic hypertension', 'carotid artery', 'carotid atherosclerosis', 'carotid intima-media thickness', 'carotid damage', 'carotid thickening'. Full articles published in the English language in the last two decades reporting studies on adults were considered. A total of 3478 untreated patients, 940 normotensive (48% men), 666 WCH (48% men), and 1872 hypertensive individuals (57% men) included in 10 studies, were analyzed. Common carotid intima-media thickness (IMT) showed a progressive increase from normotensive (718± 36 μm) to WCH (763± 47 μm, standardized mean difference 0.54 ±0.13, P

Original language	English
Pages (from-to)	57-63
Number of pages	7
Journal	Blood Pressure Monitoring
Volume	20
Issue number	2
DOIs	https://doi.org/10.1097/MBP.0000000000000094
Publication status	Published - Mar 27 2015

Keywords

ambulatory blood pressure monitoring
carotid intima-media thickness
white-coat hypertension

ASJC Scopus subject areas

Internal Medicine
Cardiology and Cardiovascular Medicine
Assessment and Diagnosis
Advanced and Specialised Nursing
Medicine(all)

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abstract = "The association of white-coat hypertension (WCH) with target organ damage is still debated; in particular, the relationship of this blood pressure phenotype with subclinical vascular damage remains controversial. Thus, we carried out a systematic review and meta-analysis to provide updated information on carotid structural changes in WCH. Studies were identified using the following search terms: 'white coat hypertension', 'isolated clinic hypertension', 'carotid artery', 'carotid atherosclerosis', 'carotid intima-media thickness', 'carotid damage', 'carotid thickening'. Full articles published in the English language in the last two decades reporting studies on adults were considered. A total of 3478 untreated patients, 940 normotensive (48% men), 666 WCH (48% men), and 1872 hypertensive individuals (57% men) included in 10 studies, were analyzed. Common carotid intima-media thickness (IMT) showed a progressive increase from normotensive (718± 36 μm) to WCH (763± 47 μm, standardized mean difference 0.54 ±0.13, P",

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AU - Sala, Carla

AU - Tadic, Marijana

AU - Rescaldani, Marta

AU - Grassi, Guido

AU - Mancia, Giuseppe

PY - 2015/3/27

Y1 - 2015/3/27

N2 - The association of white-coat hypertension (WCH) with target organ damage is still debated; in particular, the relationship of this blood pressure phenotype with subclinical vascular damage remains controversial. Thus, we carried out a systematic review and meta-analysis to provide updated information on carotid structural changes in WCH. Studies were identified using the following search terms: 'white coat hypertension', 'isolated clinic hypertension', 'carotid artery', 'carotid atherosclerosis', 'carotid intima-media thickness', 'carotid damage', 'carotid thickening'. Full articles published in the English language in the last two decades reporting studies on adults were considered. A total of 3478 untreated patients, 940 normotensive (48% men), 666 WCH (48% men), and 1872 hypertensive individuals (57% men) included in 10 studies, were analyzed. Common carotid intima-media thickness (IMT) showed a progressive increase from normotensive (718± 36 μm) to WCH (763± 47 μm, standardized mean difference 0.54 ±0.13, P

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Is white-coat hypertension a risk factor for carotid atherosclerosis? A review and meta-analysis

Abstract

Keywords

ASJC Scopus subject areas

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