Isavuconazole treatment of cerebral and pulmonary aspergillosis in a pediatric patient with acute lymphoblastic leukemia: Case report and review of literature: Journal of Pediatric Hematology/Oncology

F. De Leonardis, C. Novielli, B. Giannico, M.A. Mariggiò, E. Castagnola, N. Santoro

Research output: Contribution to journalArticlepeer-review

Abstract

Invasive aspergillosis in hematologic pediatric patients is an opportunistic infection that is difficult to treat, with a high mortality rate when localized in the central nervous system. We are describing a 3-year-old girl who was affected by acute lymphoblastic leukemia who developed cerebral and pulmonary aspergillosis during induction chemotherapy. The patient failed first-line voriconazole treatment because of being a CYP2C19 ultrarapid metabolizer and received effective isavuconazole therapy with no notable side effects. © 2020 Lippincott Williams and Wilkins. All rights reserved.
Original languageEnglish
Pages (from-to)E469-E471
JournalJ. Pediatr. Hematol. Oncol.
Volume42
Issue number6
DOIs
Publication statusPublished - 2020

Keywords

  • aspergillosis
  • CNS
  • isavuconazole
  • leukemia
  • pediatric
  • amphotericin B lipid complex
  • antileukemic agent
  • cytochrome P450 2C19
  • proton pump inhibitor
  • steroid
  • voriconazole
  • antifungal agent
  • antineoplastic agent
  • nitrile
  • pyridine derivative
  • triazole derivative
  • acute lymphoblastic leukemia
  • ALL AIEOP-BFM 2017 protocol
  • B cell leukemia
  • brain radiography
  • case report
  • central nervous system aspergillosis
  • child
  • clinical article
  • clinical protocol
  • CYP2C19 gene
  • drug blood level
  • drug dose increase
  • drug metabolism
  • drug monitoring
  • drug substitution
  • drug withdrawal
  • electroencephalogram
  • female
  • genotype
  • human
  • induction chemotherapy
  • loading drug dose
  • lung aspergillosis
  • neutropenia
  • nuclear magnetic resonance imaging
  • pancytopenia
  • patient referral
  • pediatric patient
  • preschool child
  • priority journal
  • Review
  • seizure
  • thorax radiography
  • x-ray computed tomography
  • Aspergillus
  • drug effect
  • isolation and purification
  • pathology
  • prognosis
  • Antifungal Agents
  • Antineoplastic Combined Chemotherapy Protocols
  • Child, Preschool
  • Female
  • Humans
  • Neuroaspergillosis
  • Nitriles
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Prognosis
  • Pulmonary Aspergillosis
  • Pyridines
  • Triazoles

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