Ischemic stroke across sexes: What is the status quo?

Luca Liberale, Federico Carbone, Fabrizio Montecucco, Cathérine Gebhard, Thomas F. Lüscher, Susanne Wegener, Giovanni G. Camici

Research output: Contribution to journalReview article

Abstract

Stroke prevalence is expected to increase in the next decades due to the aging of the Western population. Ischemic stroke (IS) shows an age- and sex-dependent distribution in which men represent the most affected population within 65 years of age, being passed by post-menopausal women in older age groups. Furthermore, a sexual dimorphism concerning risk factors, presentation and treatment of IS has been widely recognized. In order to address these phenomena, a number of issue have been raised involving both socio-economical and biological factors. The latter can be either dependent on sex hormones or due to intrinsic factors. Although women have poorer outcomes and are more likely to die after a cerebrovascular event, they are still underrepresented in clinical trials and this is mirrored by the lack of sex-tailored therapies. A greater effort is needed in the future to ensure improved treatment and quality of life to both sexes.

Original languageEnglish
Pages (from-to)3-17
Number of pages15
JournalFrontiers in Neuroendocrinology
Volume50
DOIs
Publication statusPublished - Jul 1 2018

Fingerprint

Stroke
Intrinsic Factor
Sex Distribution
Biological Factors
Gonadal Steroid Hormones
Sex Characteristics
Population
Therapeutics
Age Groups
Quality of Life
Clinical Trials

Keywords

  • Estrogen
  • Gender
  • Ischemic stroke
  • Progesterone
  • Sex
  • Sex chromosomes
  • Sexual dimorphism
  • Testosterone

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems

Cite this

Liberale, L., Carbone, F., Montecucco, F., Gebhard, C., Lüscher, T. F., Wegener, S., & Camici, G. G. (2018). Ischemic stroke across sexes: What is the status quo? Frontiers in Neuroendocrinology, 50, 3-17. https://doi.org/10.1016/j.yfrne.2018.05.001

Ischemic stroke across sexes : What is the status quo? / Liberale, Luca; Carbone, Federico; Montecucco, Fabrizio; Gebhard, Cathérine; Lüscher, Thomas F.; Wegener, Susanne; Camici, Giovanni G.

In: Frontiers in Neuroendocrinology, Vol. 50, 01.07.2018, p. 3-17.

Research output: Contribution to journalReview article

Liberale, L, Carbone, F, Montecucco, F, Gebhard, C, Lüscher, TF, Wegener, S & Camici, GG 2018, 'Ischemic stroke across sexes: What is the status quo?', Frontiers in Neuroendocrinology, vol. 50, pp. 3-17. https://doi.org/10.1016/j.yfrne.2018.05.001
Liberale, Luca ; Carbone, Federico ; Montecucco, Fabrizio ; Gebhard, Cathérine ; Lüscher, Thomas F. ; Wegener, Susanne ; Camici, Giovanni G. / Ischemic stroke across sexes : What is the status quo?. In: Frontiers in Neuroendocrinology. 2018 ; Vol. 50. pp. 3-17.
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