Islet Autoantibodies

Vito Lampasona, Daniela Liberati

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Islet autoantibodies are the main markers of pancreatic autoimmunity in type 1 diabetes (T1D). Islet autoantibodies recognize insulin (IAA), glutamic acid decarboxylase (GADA), protein phosphatase-like IA-2 (IA-2A), and ZnT8 (ZnT8A), all antigens that are found on secretory granules within pancreatic beta cells. Islet antibodies, measured by sensitive and specific liquid phase assays, are the key parameters of the autoimmune response monitored for diagnostics or prognostics in patients with T1D or for disease prediction in at-risk individuals before T1D onset. Islet autoantibodies have been the main tool used to explore the natural history of T1D; this review summarizes the current knowledge about the autoantigens and the phenotype of islets autoantibodies acquired in large prospective studies from birth in children at risk of developing T1D.

Original languageEnglish
Article number53
JournalCurrent Diabetes Reports
Volume16
Issue number6
DOIs
Publication statusPublished - Jun 1 2016

Fingerprint

Type 1 Diabetes Mellitus
Autoantibodies
Autoimmunity
Glutamate Decarboxylase
Phosphoprotein Phosphatases
Autoantigens
Secretory Vesicles
Insulin-Secreting Cells
Parturition
Prospective Studies
Insulin
Phenotype
Antigens
Antibodies

Keywords

  • Autoantibodies
  • GAD65
  • IA-2
  • Insulin
  • T1D
  • ZnT8

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Islet Autoantibodies. / Lampasona, Vito; Liberati, Daniela.

In: Current Diabetes Reports, Vol. 16, No. 6, 53, 01.06.2016.

Research output: Contribution to journalArticle

Lampasona, Vito ; Liberati, Daniela. / Islet Autoantibodies. In: Current Diabetes Reports. 2016 ; Vol. 16, No. 6.
@article{f9f59b43f24b40939c38bea62516bfba,
title = "Islet Autoantibodies",
abstract = "Islet autoantibodies are the main markers of pancreatic autoimmunity in type 1 diabetes (T1D). Islet autoantibodies recognize insulin (IAA), glutamic acid decarboxylase (GADA), protein phosphatase-like IA-2 (IA-2A), and ZnT8 (ZnT8A), all antigens that are found on secretory granules within pancreatic beta cells. Islet antibodies, measured by sensitive and specific liquid phase assays, are the key parameters of the autoimmune response monitored for diagnostics or prognostics in patients with T1D or for disease prediction in at-risk individuals before T1D onset. Islet autoantibodies have been the main tool used to explore the natural history of T1D; this review summarizes the current knowledge about the autoantigens and the phenotype of islets autoantibodies acquired in large prospective studies from birth in children at risk of developing T1D.",
keywords = "Autoantibodies, GAD65, IA-2, Insulin, T1D, ZnT8",
author = "Vito Lampasona and Daniela Liberati",
year = "2016",
month = "6",
day = "1",
doi = "10.1007/s11892-016-0738-2",
language = "English",
volume = "16",
journal = "Current Diabetes Reports",
issn = "1534-4827",
publisher = "Current Medicine Group",
number = "6",

}

TY - JOUR

T1 - Islet Autoantibodies

AU - Lampasona, Vito

AU - Liberati, Daniela

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Islet autoantibodies are the main markers of pancreatic autoimmunity in type 1 diabetes (T1D). Islet autoantibodies recognize insulin (IAA), glutamic acid decarboxylase (GADA), protein phosphatase-like IA-2 (IA-2A), and ZnT8 (ZnT8A), all antigens that are found on secretory granules within pancreatic beta cells. Islet antibodies, measured by sensitive and specific liquid phase assays, are the key parameters of the autoimmune response monitored for diagnostics or prognostics in patients with T1D or for disease prediction in at-risk individuals before T1D onset. Islet autoantibodies have been the main tool used to explore the natural history of T1D; this review summarizes the current knowledge about the autoantigens and the phenotype of islets autoantibodies acquired in large prospective studies from birth in children at risk of developing T1D.

AB - Islet autoantibodies are the main markers of pancreatic autoimmunity in type 1 diabetes (T1D). Islet autoantibodies recognize insulin (IAA), glutamic acid decarboxylase (GADA), protein phosphatase-like IA-2 (IA-2A), and ZnT8 (ZnT8A), all antigens that are found on secretory granules within pancreatic beta cells. Islet antibodies, measured by sensitive and specific liquid phase assays, are the key parameters of the autoimmune response monitored for diagnostics or prognostics in patients with T1D or for disease prediction in at-risk individuals before T1D onset. Islet autoantibodies have been the main tool used to explore the natural history of T1D; this review summarizes the current knowledge about the autoantigens and the phenotype of islets autoantibodies acquired in large prospective studies from birth in children at risk of developing T1D.

KW - Autoantibodies

KW - GAD65

KW - IA-2

KW - Insulin

KW - T1D

KW - ZnT8

UR - http://www.scopus.com/inward/record.url?scp=84964499658&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84964499658&partnerID=8YFLogxK

U2 - 10.1007/s11892-016-0738-2

DO - 10.1007/s11892-016-0738-2

M3 - Article

AN - SCOPUS:84964499658

VL - 16

JO - Current Diabetes Reports

JF - Current Diabetes Reports

SN - 1534-4827

IS - 6

M1 - 53

ER -