Islet Autoantibodies

Vito Lampasona, Daniela Liberati

Research output: Contribution to journalArticlepeer-review

Abstract

Islet autoantibodies are the main markers of pancreatic autoimmunity in type 1 diabetes (T1D). Islet autoantibodies recognize insulin (IAA), glutamic acid decarboxylase (GADA), protein phosphatase-like IA-2 (IA-2A), and ZnT8 (ZnT8A), all antigens that are found on secretory granules within pancreatic beta cells. Islet antibodies, measured by sensitive and specific liquid phase assays, are the key parameters of the autoimmune response monitored for diagnostics or prognostics in patients with T1D or for disease prediction in at-risk individuals before T1D onset. Islet autoantibodies have been the main tool used to explore the natural history of T1D; this review summarizes the current knowledge about the autoantigens and the phenotype of islets autoantibodies acquired in large prospective studies from birth in children at risk of developing T1D.

Original languageEnglish
Article number53
JournalCurrent Diabetes Reports
Volume16
Issue number6
DOIs
Publication statusPublished - Jun 1 2016

Keywords

  • Autoantibodies
  • GAD65
  • IA-2
  • Insulin
  • T1D
  • ZnT8

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Fingerprint Dive into the research topics of 'Islet Autoantibodies'. Together they form a unique fingerprint.

Cite this