Islet cell autoimmunity in type I diabetic patients after HLA-mismatched pancreas transplantation

E. Bosi, G. F. Bottazzo, A. Secchi, G. Pozza, M. Shattock, A. Saunders, A. Gelet, J. L. Touraine, J. Traeger, J. M. Dubernard

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Abstract

The aim of this study was to investigate a possible reenhancement of islet cell autoimmunity in type I (insulin-dependent) diabetic patients who received HLA-mismatched pancreas transplants from cadaveric donors and who underwent generalized immunosuppression. Circulating islet cell antibodies (ICA) and complement-fixing ICAs (CF-ICAs) have been tested at 1, 2, 3, 6, and 12 mo and at least once a year posttransplantation in 23 recipients of 25 transplants (22 simultaneous with kidney, 2 retransplants, 1 isolated; 23 segmental neoprene injected, 2 whole with enteric drainage). Patients were aged 35.3 ± 1.9 yr with a duration of diabetes of 20.6 ± 1.1 yr. Immunosuppression consisted of double or triple association of azathioprine, cyclosporin, and prednisone with or without temporary antilymphocyte globulins. The number of HLA-A and HLA-B compatibilities was none in 8 patients, one in 12 patients, two in 4 patients, and three in 1 patient. The mean follow-up was 4.0 ± 0.4 yr/patient (range 0.4-7.2). ICAs were positive pretransplantation in 2 of 25 patients and reappeared 1-42 mo posttransplantation in another 7. In 6 patients, CF-ICAs were also positive. In 7 of 9 ICA+ patients the pancreas transplant failed; in 1 patient this occurred 4 mo before ICA reappearance, and in 6 patients it occurred 2-35 mo after the first detection of ICAs. Pancreas-transplant failure was significantly associated with the positivity for ICAs (P

Original languageEnglish
Pages (from-to)82-84
Number of pages3
JournalDiabetes
Volume38
Issue numberSUPPL. 1
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

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    Bosi, E., Bottazzo, G. F., Secchi, A., Pozza, G., Shattock, M., Saunders, A., Gelet, A., Touraine, J. L., Traeger, J., & Dubernard, J. M. (1989). Islet cell autoimmunity in type I diabetic patients after HLA-mismatched pancreas transplantation. Diabetes, 38(SUPPL. 1), 82-84.