Islet product characteristics and factors related to successful human islet transplantation from the collaborative islet transplant registry (CITR) 1999-2010

A. N. Balamurugan; B. Naziruddin; A. Lockridge; M. Tiwari; G. Loganathan; M. Takita; S. Matsumoto; K. Papas; M. Trieger; H. Rainis; T. Kin; T. W. Kay; S. Wease; S. Messinger; C. Ricordi; R. Alejandro; J. Markmann; J. Kerr-Conti; M. R. Rickels; C. Liu; X. Zhang; P. Witkowski; A. Posselt; P. Maffi; A. Secchi; T. Berney; P. J. O'Connell; B. J. Hering; F. B. Barton

doi:10.1111/ajt.12872

Islet product characteristics and factors related to successful human islet transplantation from the collaborative islet transplant registry (CITR) 1999-2010

A. N. Balamurugan, B. Naziruddin, A. Lockridge, M. Tiwari, G. Loganathan, M. Takita, S. Matsumoto, K. Papas, M. Trieger, H. Rainis, T. Kin, T. W. Kay, S. Wease, S. Messinger, C. Ricordi, R. Alejandro, J. Markmann, J. Kerr-Conti, M. R. Rickels, C. LiuX. Zhang, P. Witkowski, A. Posselt, P. Maffi, A. Secchi, T. Berney, P. J. O'Connell, B. J. Hering, F. B. Barton

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

The Collaborative Islet Transplant Registry (CITR) collects data on clinical islet isolations and transplants. This retrospective report analyzed 1017 islet isolation procedures performed for 537 recipients of allogeneic clinical islet transplantation in 1999-2010. This study describes changes in donor and islet isolation variables by era and factors associated with quantity and quality of final islet products. Donor body weight and BMI increased significantly over the period (p <0.001). Islet yield measures have improved with time including islet equivalent (IEQ)/particle ratio and IEQs infused. The average dose of islets infused significantly increased in the era of 2007-2010 when compared to 1999-2002 (445.4 ± 156.8 vs. 421.3 ± 155.4 ×10³ IEQ; p <0.05). Islet purity and total number of β cells significantly improved over the study period (p <0.01 and

Original language	English
Pages (from-to)	2595-2606
Number of pages	12
Journal	American Journal of Transplantation
Volume	14
Issue number	11
DOIs	https://doi.org/10.1111/ajt.12872
Publication status	Published - Nov 1 2014

Keywords

Clinical research/practice
diabetes: type 1
endocrinology/diabetology
health services and outcomes research
islet isolation
islet transplantation
Organ Procurement and Transplantation Network (OPTN)
pancreas/simultaneous pancreas-kidney transplantation
registry/registry analysis

ASJC Scopus subject areas

Transplantation
Immunology and Allergy
Pharmacology (medical)

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10.1111/ajt.12872

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Balamurugan, A. N., Naziruddin, B., Lockridge, A., Tiwari, M., Loganathan, G., Takita, M., Matsumoto, S., Papas, K., Trieger, M., Rainis, H., Kin, T., Kay, T. W., Wease, S., Messinger, S., Ricordi, C., Alejandro, R., Markmann, J., Kerr-Conti, J., Rickels, M. R., ... Barton, F. B. (2014). Islet product characteristics and factors related to successful human islet transplantation from the collaborative islet transplant registry (CITR) 1999-2010. American Journal of Transplantation, 14(11), 2595-2606. https://doi.org/10.1111/ajt.12872

Balamurugan, AN, Naziruddin, B, Lockridge, A, Tiwari, M, Loganathan, G, Takita, M, Matsumoto, S, Papas, K, Trieger, M, Rainis, H, Kin, T, Kay, TW, Wease, S, Messinger, S, Ricordi, C, Alejandro, R, Markmann, J, Kerr-Conti, J, Rickels, MR, Liu, C, Zhang, X, Witkowski, P, Posselt, A, Maffi, P , Secchi, A, Berney, T, O'Connell, PJ, Hering, BJ & Barton, FB 2014, 'Islet product characteristics and factors related to successful human islet transplantation from the collaborative islet transplant registry (CITR) 1999-2010', American Journal of Transplantation, vol. 14, no. 11, pp. 2595-2606. https://doi.org/10.1111/ajt.12872

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title = "Islet product characteristics and factors related to successful human islet transplantation from the collaborative islet transplant registry (CITR) 1999-2010",

abstract = "The Collaborative Islet Transplant Registry (CITR) collects data on clinical islet isolations and transplants. This retrospective report analyzed 1017 islet isolation procedures performed for 537 recipients of allogeneic clinical islet transplantation in 1999-2010. This study describes changes in donor and islet isolation variables by era and factors associated with quantity and quality of final islet products. Donor body weight and BMI increased significantly over the period (p <0.001). Islet yield measures have improved with time including islet equivalent (IEQ)/particle ratio and IEQs infused. The average dose of islets infused significantly increased in the era of 2007-2010 when compared to 1999-2002 (445.4 ± 156.8 vs. 421.3 ± 155.4 ×103 IEQ; p <0.05). Islet purity and total number of β cells significantly improved over the study period (p <0.01 and ",

keywords = "Clinical research/practice, diabetes: type 1, endocrinology/diabetology, health services and outcomes research, islet isolation, islet transplantation, Organ Procurement and Transplantation Network (OPTN), pancreas/simultaneous pancreas-kidney transplantation, registry/registry analysis",

author = "Balamurugan, {A. N.} and B. Naziruddin and A. Lockridge and M. Tiwari and G. Loganathan and M. Takita and S. Matsumoto and K. Papas and M. Trieger and H. Rainis and T. Kin and Kay, {T. W.} and S. Wease and S. Messinger and C. Ricordi and R. Alejandro and J. Markmann and J. Kerr-Conti and Rickels, {M. R.} and C. Liu and X. Zhang and P. Witkowski and A. Posselt and P. Maffi and A. Secchi and T. Berney and O'Connell, {P. J.} and Hering, {B. J.} and Barton, {F. B.}",

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doi = "10.1111/ajt.12872",

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AU - Balamurugan, A. N.

AU - Naziruddin, B.

AU - Lockridge, A.

AU - Tiwari, M.

AU - Loganathan, G.

AU - Takita, M.

AU - Matsumoto, S.

AU - Papas, K.

AU - Trieger, M.

AU - Rainis, H.

AU - Kin, T.

AU - Kay, T. W.

AU - Wease, S.

AU - Messinger, S.

AU - Ricordi, C.

AU - Alejandro, R.

AU - Markmann, J.

AU - Kerr-Conti, J.

AU - Rickels, M. R.

AU - Liu, C.

AU - Zhang, X.

AU - Witkowski, P.

AU - Posselt, A.

AU - Maffi, P.

AU - Secchi, A.

AU - Berney, T.

AU - O'Connell, P. J.

AU - Hering, B. J.

AU - Barton, F. B.

PY - 2014/11/1

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N2 - The Collaborative Islet Transplant Registry (CITR) collects data on clinical islet isolations and transplants. This retrospective report analyzed 1017 islet isolation procedures performed for 537 recipients of allogeneic clinical islet transplantation in 1999-2010. This study describes changes in donor and islet isolation variables by era and factors associated with quantity and quality of final islet products. Donor body weight and BMI increased significantly over the period (p <0.001). Islet yield measures have improved with time including islet equivalent (IEQ)/particle ratio and IEQs infused. The average dose of islets infused significantly increased in the era of 2007-2010 when compared to 1999-2002 (445.4 ± 156.8 vs. 421.3 ± 155.4 ×103 IEQ; p <0.05). Islet purity and total number of β cells significantly improved over the study period (p <0.01 and

AB - The Collaborative Islet Transplant Registry (CITR) collects data on clinical islet isolations and transplants. This retrospective report analyzed 1017 islet isolation procedures performed for 537 recipients of allogeneic clinical islet transplantation in 1999-2010. This study describes changes in donor and islet isolation variables by era and factors associated with quantity and quality of final islet products. Donor body weight and BMI increased significantly over the period (p <0.001). Islet yield measures have improved with time including islet equivalent (IEQ)/particle ratio and IEQs infused. The average dose of islets infused significantly increased in the era of 2007-2010 when compared to 1999-2002 (445.4 ± 156.8 vs. 421.3 ± 155.4 ×103 IEQ; p <0.05). Islet purity and total number of β cells significantly improved over the study period (p <0.01 and

KW - Clinical research/practice

KW - diabetes: type 1

KW - endocrinology/diabetology

KW - health services and outcomes research

KW - islet isolation

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KW - Organ Procurement and Transplantation Network (OPTN)

KW - pancreas/simultaneous pancreas-kidney transplantation

KW - registry/registry analysis

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JO - American Journal of Transplantation

JF - American Journal of Transplantation

SN - 1600-6135

IS - 11

ER -

Islet product characteristics and factors related to successful human islet transplantation from the collaborative islet transplant registry (CITR) 1999-2010

Abstract

Keywords

ASJC Scopus subject areas

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