Abstract
The Collaborative Islet Transplant Registry (CITR) collects data on clinical islet isolations and transplants. This retrospective report analyzed 1017 islet isolation procedures performed for 537 recipients of allogeneic clinical islet transplantation in 1999-2010. This study describes changes in donor and islet isolation variables by era and factors associated with quantity and quality of final islet products. Donor body weight and BMI increased significantly over the period (p <0.001). Islet yield measures have improved with time including islet equivalent (IEQ)/particle ratio and IEQs infused. The average dose of islets infused significantly increased in the era of 2007-2010 when compared to 1999-2002 (445.4 ± 156.8 vs. 421.3 ± 155.4 ×103 IEQ; p <0.05). Islet purity and total number of β cells significantly improved over the study period (p <0.01 and
Original language | English |
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Pages (from-to) | 2595-2606 |
Number of pages | 12 |
Journal | American Journal of Transplantation |
Volume | 14 |
Issue number | 11 |
DOIs | |
Publication status | Published - Nov 1 2014 |
Keywords
- Clinical research/practice
- diabetes: type 1
- endocrinology/diabetology
- health services and outcomes research
- islet isolation
- islet transplantation
- Organ Procurement and Transplantation Network (OPTN)
- pancreas/simultaneous pancreas-kidney transplantation
- registry/registry analysis
ASJC Scopus subject areas
- Transplantation
- Immunology and Allergy
- Pharmacology (medical)