Islet product characteristics and factors related to successful human islet transplantation from the collaborative islet transplant registry (CITR) 1999-2010

A. N. Balamurugan; B. Naziruddin; A. Lockridge; M. Tiwari; G. Loganathan; M. Takita; S. Matsumoto; K. Papas; M. Trieger; H. Rainis; T. Kin; T. W. Kay; S. Wease; S. Messinger; C. Ricordi; R. Alejandro; J. Markmann; J. Kerr-Conti; M. R. Rickels; C. Liu; X. Zhang; P. Witkowski; A. Posselt; P. Maffi; A. Secchi; T. Berney; P. J. O'Connell; B. J. Hering; F. B. Barton

doi:10.1111/ajt.12872

Islet product characteristics and factors related to successful human islet transplantation from the collaborative islet transplant registry (CITR) 1999-2010

A. N. Balamurugan, B. Naziruddin, A. Lockridge, M. Tiwari, G. Loganathan, M. Takita, S. Matsumoto, K. Papas, M. Trieger, H. Rainis, T. Kin, T. W. Kay, S. Wease, S. Messinger, C. Ricordi, R. Alejandro, J. Markmann, J. Kerr-Conti, M. R. Rickels, C. LiuX. Zhang, P. Witkowski, A. Posselt, P. Maffi, A. Secchi, T. Berney, P. J. O'Connell, B. J. Hering, F. B. Barton

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article

Abstract

The Collaborative Islet Transplant Registry (CITR) collects data on clinical islet isolations and transplants. This retrospective report analyzed 1017 islet isolation procedures performed for 537 recipients of allogeneic clinical islet transplantation in 1999-2010. This study describes changes in donor and islet isolation variables by era and factors associated with quantity and quality of final islet products. Donor body weight and BMI increased significantly over the period (p <0.001). Islet yield measures have improved with time including islet equivalent (IEQ)/particle ratio and IEQs infused. The average dose of islets infused significantly increased in the era of 2007-2010 when compared to 1999-2002 (445.4 ± 156.8 vs. 421.3 ± 155.4 ×10³ IEQ; p <0.05). Islet purity and total number of β cells significantly improved over the study period (p <0.01 and

Original language	English
Pages (from-to)	2595-2606
Number of pages	12
Journal	American Journal of Transplantation
Volume	14
Issue number	11
DOIs	https://doi.org/10.1111/ajt.12872
Publication status	Published - Nov 1 2014

Keywords

Clinical research/practice
diabetes: type 1
endocrinology/diabetology
health services and outcomes research
islet isolation
islet transplantation
Organ Procurement and Transplantation Network (OPTN)
pancreas/simultaneous pancreas-kidney transplantation
registry/registry analysis

ASJC Scopus subject areas

Transplantation
Immunology and Allergy
Pharmacology (medical)

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10.1111/ajt.12872

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Balamurugan, A. N., Naziruddin, B., Lockridge, A., Tiwari, M., Loganathan, G., Takita, M., Matsumoto, S., Papas, K., Trieger, M., Rainis, H., Kin, T., Kay, T. W., Wease, S., Messinger, S., Ricordi, C., Alejandro, R., Markmann, J., Kerr-Conti, J., Rickels, M. R., ... Barton, F. B. (2014). Islet product characteristics and factors related to successful human islet transplantation from the collaborative islet transplant registry (CITR) 1999-2010. American Journal of Transplantation, 14(11), 2595-2606. https://doi.org/10.1111/ajt.12872

Islet product characteristics and factors related to successful human islet transplantation from the collaborative islet transplant registry (CITR) 1999-2010. / Balamurugan, A. N.; Naziruddin, B.; Lockridge, A.; Tiwari, M.; Loganathan, G.; Takita, M.; Matsumoto, S.; Papas, K.; Trieger, M.; Rainis, H.; Kin, T.; Kay, T. W.; Wease, S.; Messinger, S.; Ricordi, C.; Alejandro, R.; Markmann, J.; Kerr-Conti, J.; Rickels, M. R.; Liu, C.; Zhang, X.; Witkowski, P.; Posselt, A.; Maffi, P.; Secchi, A.; Berney, T.; O'Connell, P. J.; Hering, B. J.; Barton, F. B.

In: American Journal of Transplantation, Vol. 14, No. 11, 01.11.2014, p. 2595-2606.

Research output: Contribution to journal › Article

Balamurugan, AN, Naziruddin, B, Lockridge, A, Tiwari, M, Loganathan, G, Takita, M, Matsumoto, S, Papas, K, Trieger, M, Rainis, H, Kin, T, Kay, TW, Wease, S, Messinger, S, Ricordi, C, Alejandro, R, Markmann, J, Kerr-Conti, J, Rickels, MR, Liu, C, Zhang, X, Witkowski, P, Posselt, A, Maffi, P , Secchi, A, Berney, T, O'Connell, PJ, Hering, BJ & Barton, FB 2014, 'Islet product characteristics and factors related to successful human islet transplantation from the collaborative islet transplant registry (CITR) 1999-2010', American Journal of Transplantation, vol. 14, no. 11, pp. 2595-2606. https://doi.org/10.1111/ajt.12872

Balamurugan, A. N. ; Naziruddin, B. ; Lockridge, A. ; Tiwari, M. ; Loganathan, G. ; Takita, M. ; Matsumoto, S. ; Papas, K. ; Trieger, M. ; Rainis, H. ; Kin, T. ; Kay, T. W. ; Wease, S. ; Messinger, S. ; Ricordi, C. ; Alejandro, R. ; Markmann, J. ; Kerr-Conti, J. ; Rickels, M. R. ; Liu, C. ; Zhang, X. ; Witkowski, P. ; Posselt, A. ; Maffi, P. ; Secchi, A. ; Berney, T. ; O'Connell, P. J. ; Hering, B. J. ; Barton, F. B. / Islet product characteristics and factors related to successful human islet transplantation from the collaborative islet transplant registry (CITR) 1999-2010. In: American Journal of Transplantation. 2014 ; Vol. 14, No. 11. pp. 2595-2606.

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AU - Balamurugan, A. N.

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AU - Lockridge, A.

AU - Tiwari, M.

AU - Loganathan, G.

AU - Takita, M.

AU - Matsumoto, S.

AU - Papas, K.

AU - Trieger, M.

AU - Rainis, H.

AU - Kin, T.

AU - Kay, T. W.

AU - Wease, S.

AU - Messinger, S.

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AU - Markmann, J.

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AU - Rickels, M. R.

AU - Liu, C.

AU - Zhang, X.

AU - Witkowski, P.

AU - Posselt, A.

AU - Maffi, P.

AU - Secchi, A.

AU - Berney, T.

AU - O'Connell, P. J.

AU - Hering, B. J.

AU - Barton, F. B.

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