Islet product characteristics and factors related to successful human islet transplantation from the collaborative islet transplant registry (CITR) 1999-2010

A. N. Balamurugan, B. Naziruddin, A. Lockridge, M. Tiwari, G. Loganathan, M. Takita, S. Matsumoto, K. Papas, M. Trieger, H. Rainis, T. Kin, T. W. Kay, S. Wease, S. Messinger, C. Ricordi, R. Alejandro, J. Markmann, J. Kerr-Conti, M. R. Rickels, C. LiuX. Zhang, P. Witkowski, A. Posselt, P. Maffi, A. Secchi, T. Berney, P. J. O'Connell, B. J. Hering, F. B. Barton

Research output: Contribution to journalArticle

Abstract

The Collaborative Islet Transplant Registry (CITR) collects data on clinical islet isolations and transplants. This retrospective report analyzed 1017 islet isolation procedures performed for 537 recipients of allogeneic clinical islet transplantation in 1999-2010. This study describes changes in donor and islet isolation variables by era and factors associated with quantity and quality of final islet products. Donor body weight and BMI increased significantly over the period (p <0.001). Islet yield measures have improved with time including islet equivalent (IEQ)/particle ratio and IEQs infused. The average dose of islets infused significantly increased in the era of 2007-2010 when compared to 1999-2002 (445.4 ± 156.8 vs. 421.3 ± 155.4 ×103 IEQ; p <0.05). Islet purity and total number of β cells significantly improved over the study period (p <0.01 and

Original languageEnglish
Pages (from-to)2595-2606
Number of pages12
JournalAmerican Journal of Transplantation
Volume14
Issue number11
DOIs
Publication statusPublished - Nov 1 2014

Keywords

  • Clinical research/practice
  • diabetes: type 1
  • endocrinology/diabetology
  • health services and outcomes research
  • islet isolation
  • islet transplantation
  • Organ Procurement and Transplantation Network (OPTN)
  • pancreas/simultaneous pancreas-kidney transplantation
  • registry/registry analysis

ASJC Scopus subject areas

  • Transplantation
  • Immunology and Allergy
  • Pharmacology (medical)

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    Balamurugan, A. N., Naziruddin, B., Lockridge, A., Tiwari, M., Loganathan, G., Takita, M., Matsumoto, S., Papas, K., Trieger, M., Rainis, H., Kin, T., Kay, T. W., Wease, S., Messinger, S., Ricordi, C., Alejandro, R., Markmann, J., Kerr-Conti, J., Rickels, M. R., ... Barton, F. B. (2014). Islet product characteristics and factors related to successful human islet transplantation from the collaborative islet transplant registry (CITR) 1999-2010. American Journal of Transplantation, 14(11), 2595-2606. https://doi.org/10.1111/ajt.12872