Abstract
The Collaborative Islet Transplant Registry (CITR) collects data on clinical islet isolations and transplants. This retrospective report analyzed 1017 islet isolation procedures performed for 537 recipients of allogeneic clinical islet transplantation in 1999-2010. This study describes changes in donor and islet isolation variables by era and factors associated with quantity and quality of final islet products. Donor body weight and BMI increased significantly over the period (p <0.001). Islet yield measures have improved with time including islet equivalent (IEQ)/particle ratio and IEQs infused. The average dose of islets infused significantly increased in the era of 2007-2010 when compared to 1999-2002 (445.4 ± 156.8 vs. 421.3 ± 155.4 ×103 IEQ; p <0.05). Islet purity and total number of β cells significantly improved over the study period (p <0.01 and
| Original language | English |
|---|---|
| Pages (from-to) | 2595-2606 |
| Number of pages | 12 |
| Journal | American Journal of Transplantation |
| Volume | 14 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Nov 1 2014 |
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Keywords
- Clinical research/practice
- diabetes: type 1
- endocrinology/diabetology
- health services and outcomes research
- islet isolation
- islet transplantation
- Organ Procurement and Transplantation Network (OPTN)
- pancreas/simultaneous pancreas-kidney transplantation
- registry/registry analysis
ASJC Scopus subject areas
- Transplantation
- Immunology and Allergy
- Pharmacology (medical)
Cite this
Islet product characteristics and factors related to successful human islet transplantation from the collaborative islet transplant registry (CITR) 1999-2010. / Balamurugan, A. N.; Naziruddin, B.; Lockridge, A.; Tiwari, M.; Loganathan, G.; Takita, M.; Matsumoto, S.; Papas, K.; Trieger, M.; Rainis, H.; Kin, T.; Kay, T. W.; Wease, S.; Messinger, S.; Ricordi, C.; Alejandro, R.; Markmann, J.; Kerr-Conti, J.; Rickels, M. R.; Liu, C.; Zhang, X.; Witkowski, P.; Posselt, A.; Maffi, P.; Secchi, A.; Berney, T.; O'Connell, P. J.; Hering, B. J.; Barton, F. B.
In: American Journal of Transplantation, Vol. 14, No. 11, 01.11.2014, p. 2595-2606.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Islet product characteristics and factors related to successful human islet transplantation from the collaborative islet transplant registry (CITR) 1999-2010
AU - Balamurugan, A. N.
AU - Naziruddin, B.
AU - Lockridge, A.
AU - Tiwari, M.
AU - Loganathan, G.
AU - Takita, M.
AU - Matsumoto, S.
AU - Papas, K.
AU - Trieger, M.
AU - Rainis, H.
AU - Kin, T.
AU - Kay, T. W.
AU - Wease, S.
AU - Messinger, S.
AU - Ricordi, C.
AU - Alejandro, R.
AU - Markmann, J.
AU - Kerr-Conti, J.
AU - Rickels, M. R.
AU - Liu, C.
AU - Zhang, X.
AU - Witkowski, P.
AU - Posselt, A.
AU - Maffi, P.
AU - Secchi, A.
AU - Berney, T.
AU - O'Connell, P. J.
AU - Hering, B. J.
AU - Barton, F. B.
PY - 2014/11/1
Y1 - 2014/11/1
N2 - The Collaborative Islet Transplant Registry (CITR) collects data on clinical islet isolations and transplants. This retrospective report analyzed 1017 islet isolation procedures performed for 537 recipients of allogeneic clinical islet transplantation in 1999-2010. This study describes changes in donor and islet isolation variables by era and factors associated with quantity and quality of final islet products. Donor body weight and BMI increased significantly over the period (p <0.001). Islet yield measures have improved with time including islet equivalent (IEQ)/particle ratio and IEQs infused. The average dose of islets infused significantly increased in the era of 2007-2010 when compared to 1999-2002 (445.4 ± 156.8 vs. 421.3 ± 155.4 ×103 IEQ; p <0.05). Islet purity and total number of β cells significantly improved over the study period (p <0.01 and
AB - The Collaborative Islet Transplant Registry (CITR) collects data on clinical islet isolations and transplants. This retrospective report analyzed 1017 islet isolation procedures performed for 537 recipients of allogeneic clinical islet transplantation in 1999-2010. This study describes changes in donor and islet isolation variables by era and factors associated with quantity and quality of final islet products. Donor body weight and BMI increased significantly over the period (p <0.001). Islet yield measures have improved with time including islet equivalent (IEQ)/particle ratio and IEQs infused. The average dose of islets infused significantly increased in the era of 2007-2010 when compared to 1999-2002 (445.4 ± 156.8 vs. 421.3 ± 155.4 ×103 IEQ; p <0.05). Islet purity and total number of β cells significantly improved over the study period (p <0.01 and
KW - Clinical research/practice
KW - diabetes: type 1
KW - endocrinology/diabetology
KW - health services and outcomes research
KW - islet isolation
KW - islet transplantation
KW - Organ Procurement and Transplantation Network (OPTN)
KW - pancreas/simultaneous pancreas-kidney transplantation
KW - registry/registry analysis
UR - http://www.scopus.com/inward/record.url?scp=84911391841&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84911391841&partnerID=8YFLogxK
U2 - 10.1111/ajt.12872
DO - 10.1111/ajt.12872
M3 - Article
C2 - 25278159
AN - SCOPUS:84911391841
VL - 14
SP - 2595
EP - 2606
JO - American Journal of Transplantation
JF - American Journal of Transplantation
SN - 1600-6135
IS - 11
ER -