Islet Transplantation Alone Versus Solitary Pancreas Transplantation: an Outcome-Driven Choice?

Research output: Contribution to journalReview article

Abstract

Purpose of review: In patients with type 1 diabetes with extreme glycemic variability, the restoration of pancreas endocrine function is potentially and completely achieved with islets of Langerhans (tissue derived from whole organ) or pancreas (whole organ) transplantation. The aim of our review is to report on the latest studies and to highlight the benefits and risks of the two procedures, providing clearer, more selective, evidence-based clinical indications that also consider the impact on the degenerative complications of diabetes as a potential benefit. Recent findings: Clinical experience in this field has been dynamic over the last three decades, and has been characterized by the development of more standardized protocols and a clearer definition of clinical outcome. On the contrary, the recommendations thus far are not well delineated and tend to overlap, and the past ADA position statement for pancreas transplant alone has also been applied to islet transplant alone, without differentiation. Summary: Both outcome-driven and non-outcome-driven criteria are considered in the conclusions, in an attempt to streamline indications for islet-alone or pancreas-alone transplantation.

Original languageEnglish
Article number26
JournalCurrent Diabetes Reports
Volume19
Issue number5
DOIs
Publication statusPublished - May 1 2019

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Keywords

  • Chronic complications
  • Indications for transplantation
  • Islet transplantations
  • Metabolic complications
  • Pancreas transplantation
  • Type 1 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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