Isn’t functional neuroimaging all about ca2+ signaling in astrocytes?

Mauro Dinuzzo

Research output: Contribution to journalArticlepeer-review


Extensive research over the past decades about the multifaceted roles of brain astrocytes led to the suggestion that the signals observed with functional neuroimaging might primarily reflect astrocytic rather than neuronal activity. The basis for this paradigm-shifting concept was the evidence for an involvement of astrocytes in the control of local cerebral blood flow through intracellular Ca2+ signaling. In this Neuro Forum, I discuss new important experimental findings obtained by Jego et al. (Jego P, Pacheco-Torres J, Araque A, Canals S. J Cereb Blood Flow Metab 34: 1599–1603, 2014) as well as other closely related studies published recently, prompting a dismissal of substantial astrocytic contribution in functional neuroimaging.

Original languageEnglish
Pages (from-to)1353-1356
Number of pages4
JournalJournal of Neurophysiology
Issue number3
Publication statusPublished - Sep 1 2015


  • Astrocytic Ca<sup>2+</sup> signaling
  • Neurovascular coupling

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)


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