Isochromosome 12p-positive pineal germ cell tumor

Tjerk W A De Bruin; Rosalyn M. Slater; Rafaella Defferrari; Ad Geurts Van Kessel; Ron F. Suijkerbuijk; Gerard Jansen; Bauke De Jong; J. Wolter Oosterhuis

Isochromosome 12p-positive pineal germ cell tumor

Tjerk W A De Bruin, Rosalyn M. Slater, Rafaella Defferrari, Ad Geurts Van Kessel, Ron F. Suijkerbuijk, Gerard Jansen, Bauke De Jong, J. Wolter Oosterhuis

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Article › peer-review

Abstract

We report the chromosomal characteristics of a recurrent pineal non- seminomatous germ cell tumor in a 16-year-old male patient. This non- seminomatous tumor had the following components: embryonal carcinoma, teratoma, yolk sac tumor, and trophoblastic giant cells. Chromosome analysis showed a near-triploid karyotype (64 chromosomes), including two copies of an isochromosome 12p. This latter finding could be confirmed using 12p-specific competitive in situ hybridization techniques applied to cultured cells (T2219-P6 cell line) derived from the tumor. The present findings are in keeping with the hypothesis that isochromosome 12p formation is associated with the development of malignant extragonadal germ cell tumors.

Original language	English
Pages (from-to)	1542-1544
Number of pages	3
Journal	Cancer Research
Volume	54
Issue number	6
Publication status	Published - Mar 15 1994

ASJC Scopus subject areas

Cancer Research
Oncology

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title = "Isochromosome 12p-positive pineal germ cell tumor",

abstract = "We report the chromosomal characteristics of a recurrent pineal non- seminomatous germ cell tumor in a 16-year-old male patient. This non- seminomatous tumor had the following components: embryonal carcinoma, teratoma, yolk sac tumor, and trophoblastic giant cells. Chromosome analysis showed a near-triploid karyotype (64 chromosomes), including two copies of an isochromosome 12p. This latter finding could be confirmed using 12p-specific competitive in situ hybridization techniques applied to cultured cells (T2219-P6 cell line) derived from the tumor. The present findings are in keeping with the hypothesis that isochromosome 12p formation is associated with the development of malignant extragonadal germ cell tumors.",

author = "{De Bruin}, {Tjerk W A} and Slater, {Rosalyn M.} and Rafaella Defferrari and {Van Kessel}, {Ad Geurts} and Suijkerbuijk, {Ron F.} and Gerard Jansen and {De Jong}, Bauke and Oosterhuis, {J. Wolter}",

year = "1994",

month = mar,

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language = "English",

volume = "54",

pages = "1542--1544",

journal = "Journal of Cancer Research",

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T1 - Isochromosome 12p-positive pineal germ cell tumor

AU - De Bruin, Tjerk W A

AU - Slater, Rosalyn M.

AU - Defferrari, Rafaella

AU - Van Kessel, Ad Geurts

AU - Suijkerbuijk, Ron F.

AU - Jansen, Gerard

AU - De Jong, Bauke

AU - Oosterhuis, J. Wolter

PY - 1994/3/15

Y1 - 1994/3/15

N2 - We report the chromosomal characteristics of a recurrent pineal non- seminomatous germ cell tumor in a 16-year-old male patient. This non- seminomatous tumor had the following components: embryonal carcinoma, teratoma, yolk sac tumor, and trophoblastic giant cells. Chromosome analysis showed a near-triploid karyotype (64 chromosomes), including two copies of an isochromosome 12p. This latter finding could be confirmed using 12p-specific competitive in situ hybridization techniques applied to cultured cells (T2219-P6 cell line) derived from the tumor. The present findings are in keeping with the hypothesis that isochromosome 12p formation is associated with the development of malignant extragonadal germ cell tumors.

AB - We report the chromosomal characteristics of a recurrent pineal non- seminomatous germ cell tumor in a 16-year-old male patient. This non- seminomatous tumor had the following components: embryonal carcinoma, teratoma, yolk sac tumor, and trophoblastic giant cells. Chromosome analysis showed a near-triploid karyotype (64 chromosomes), including two copies of an isochromosome 12p. This latter finding could be confirmed using 12p-specific competitive in situ hybridization techniques applied to cultured cells (T2219-P6 cell line) derived from the tumor. The present findings are in keeping with the hypothesis that isochromosome 12p formation is associated with the development of malignant extragonadal germ cell tumors.

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