Isochromosome 12p-positive pineal germ cell tumor

Tjerk W A De Bruin, Rosalyn M. Slater, Rafaella Defferrari, Ad Geurts Van Kessel, Ron F. Suijkerbuijk, Gerard Jansen, Bauke De Jong, J. Wolter Oosterhuis

Research output: Contribution to journalArticlepeer-review

Abstract

We report the chromosomal characteristics of a recurrent pineal non- seminomatous germ cell tumor in a 16-year-old male patient. This non- seminomatous tumor had the following components: embryonal carcinoma, teratoma, yolk sac tumor, and trophoblastic giant cells. Chromosome analysis showed a near-triploid karyotype (64 chromosomes), including two copies of an isochromosome 12p. This latter finding could be confirmed using 12p-specific competitive in situ hybridization techniques applied to cultured cells (T2219-P6 cell line) derived from the tumor. The present findings are in keeping with the hypothesis that isochromosome 12p formation is associated with the development of malignant extragonadal germ cell tumors.

Original languageEnglish
Pages (from-to)1542-1544
Number of pages3
JournalCancer Research
Volume54
Issue number6
Publication statusPublished - Mar 15 1994

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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