Isochromosome 12p-positive pineal germ cell tumor

Tjerk W A De Bruin, Rosalyn M. Slater, Rafaella Defferrari, Ad Geurts Van Kessel, Ron F. Suijkerbuijk, Gerard Jansen, Bauke De Jong, J. Wolter Oosterhuis

Research output: Contribution to journalArticle

Abstract

We report the chromosomal characteristics of a recurrent pineal non- seminomatous germ cell tumor in a 16-year-old male patient. This non- seminomatous tumor had the following components: embryonal carcinoma, teratoma, yolk sac tumor, and trophoblastic giant cells. Chromosome analysis showed a near-triploid karyotype (64 chromosomes), including two copies of an isochromosome 12p. This latter finding could be confirmed using 12p-specific competitive in situ hybridization techniques applied to cultured cells (T2219-P6 cell line) derived from the tumor. The present findings are in keeping with the hypothesis that isochromosome 12p formation is associated with the development of malignant extragonadal germ cell tumors.

Original languageEnglish
Pages (from-to)1542-1544
Number of pages3
JournalCancer Research
Volume54
Issue number6
Publication statusPublished - Mar 15 1994

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Isochromosomes
Pinealoma
Germ Cell and Embryonal Neoplasms
Chromosomes
Embryonal Carcinoma
Endodermal Sinus Tumor
Triploidy
Teratoma
Giant Cells
Tumor Cell Line
Karyotype
In Situ Hybridization
Cultured Cells
Neoplasms
Nonseminomatous germ cell tumor

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

De Bruin, T. W. A., Slater, R. M., Defferrari, R., Van Kessel, A. G., Suijkerbuijk, R. F., Jansen, G., ... Oosterhuis, J. W. (1994). Isochromosome 12p-positive pineal germ cell tumor. Cancer Research, 54(6), 1542-1544.

Isochromosome 12p-positive pineal germ cell tumor. / De Bruin, Tjerk W A; Slater, Rosalyn M.; Defferrari, Rafaella; Van Kessel, Ad Geurts; Suijkerbuijk, Ron F.; Jansen, Gerard; De Jong, Bauke; Oosterhuis, J. Wolter.

In: Cancer Research, Vol. 54, No. 6, 15.03.1994, p. 1542-1544.

Research output: Contribution to journalArticle

De Bruin, TWA, Slater, RM, Defferrari, R, Van Kessel, AG, Suijkerbuijk, RF, Jansen, G, De Jong, B & Oosterhuis, JW 1994, 'Isochromosome 12p-positive pineal germ cell tumor', Cancer Research, vol. 54, no. 6, pp. 1542-1544.
De Bruin TWA, Slater RM, Defferrari R, Van Kessel AG, Suijkerbuijk RF, Jansen G et al. Isochromosome 12p-positive pineal germ cell tumor. Cancer Research. 1994 Mar 15;54(6):1542-1544.
De Bruin, Tjerk W A ; Slater, Rosalyn M. ; Defferrari, Rafaella ; Van Kessel, Ad Geurts ; Suijkerbuijk, Ron F. ; Jansen, Gerard ; De Jong, Bauke ; Oosterhuis, J. Wolter. / Isochromosome 12p-positive pineal germ cell tumor. In: Cancer Research. 1994 ; Vol. 54, No. 6. pp. 1542-1544.
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