Abstract
We report the chromosomal characteristics of a recurrent pineal non- seminomatous germ cell tumor in a 16-year-old male patient. This non- seminomatous tumor had the following components: embryonal carcinoma, teratoma, yolk sac tumor, and trophoblastic giant cells. Chromosome analysis showed a near-triploid karyotype (64 chromosomes), including two copies of an isochromosome 12p. This latter finding could be confirmed using 12p-specific competitive in situ hybridization techniques applied to cultured cells (T2219-P6 cell line) derived from the tumor. The present findings are in keeping with the hypothesis that isochromosome 12p formation is associated with the development of malignant extragonadal germ cell tumors.
| Original language | English |
|---|---|
| Pages (from-to) | 1542-1544 |
| Number of pages | 3 |
| Journal | Cancer Research |
| Volume | 54 |
| Issue number | 6 |
| Publication status | Published - Mar 15 1994 |
Fingerprint
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Isochromosome 12p-positive pineal germ cell tumor. / De Bruin, Tjerk W A; Slater, Rosalyn M.; Defferrari, Rafaella; Van Kessel, Ad Geurts; Suijkerbuijk, Ron F.; Jansen, Gerard; De Jong, Bauke; Oosterhuis, J. Wolter.
In: Cancer Research, Vol. 54, No. 6, 15.03.1994, p. 1542-1544.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Isochromosome 12p-positive pineal germ cell tumor
AU - De Bruin, Tjerk W A
AU - Slater, Rosalyn M.
AU - Defferrari, Rafaella
AU - Van Kessel, Ad Geurts
AU - Suijkerbuijk, Ron F.
AU - Jansen, Gerard
AU - De Jong, Bauke
AU - Oosterhuis, J. Wolter
PY - 1994/3/15
Y1 - 1994/3/15
N2 - We report the chromosomal characteristics of a recurrent pineal non- seminomatous germ cell tumor in a 16-year-old male patient. This non- seminomatous tumor had the following components: embryonal carcinoma, teratoma, yolk sac tumor, and trophoblastic giant cells. Chromosome analysis showed a near-triploid karyotype (64 chromosomes), including two copies of an isochromosome 12p. This latter finding could be confirmed using 12p-specific competitive in situ hybridization techniques applied to cultured cells (T2219-P6 cell line) derived from the tumor. The present findings are in keeping with the hypothesis that isochromosome 12p formation is associated with the development of malignant extragonadal germ cell tumors.
AB - We report the chromosomal characteristics of a recurrent pineal non- seminomatous germ cell tumor in a 16-year-old male patient. This non- seminomatous tumor had the following components: embryonal carcinoma, teratoma, yolk sac tumor, and trophoblastic giant cells. Chromosome analysis showed a near-triploid karyotype (64 chromosomes), including two copies of an isochromosome 12p. This latter finding could be confirmed using 12p-specific competitive in situ hybridization techniques applied to cultured cells (T2219-P6 cell line) derived from the tumor. The present findings are in keeping with the hypothesis that isochromosome 12p formation is associated with the development of malignant extragonadal germ cell tumors.
UR - http://www.scopus.com/inward/record.url?scp=0028230047&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028230047&partnerID=8YFLogxK
M3 - Article
C2 - 8137260
AN - SCOPUS:0028230047
VL - 54
SP - 1542
EP - 1544
JO - Journal of Cancer Research
JF - Journal of Cancer Research
SN - 0008-5472
IS - 6
ER -