IsoDGR-Tagged Albumin: A New αvβ3 Selective Carrier for Nanodrug Delivery to Tumors

Flavio Curnis, Angelina Sacchi, Renato Longhi, Barbara Colombo, Anna Gasparri, Angelo Corti

Research output: Contribution to journalArticlepeer-review

Abstract

A new cyclic peptide containing the isoDGR motif that, after coupling to albumin, selectively binds αvβ3, an integrin overexpressed in the tumor vasculature. IsoDGR-tagged albumin binds tumor vessels and can be exploited as a carrier for the preparation of tumor vasculature-selective nanomedicines, such as gold nanoparticles (Au) carrying tumor necrosis factor α (TNF), a potent vascular damaging agent.

Original languageEnglish
Pages (from-to)673-678
Number of pages6
JournalSmall
Volume9
Issue number5
DOIs
Publication statusPublished - Mar 11 2013

Keywords

  • cyclic peptides
  • drug delivery
  • gold nanoparticles
  • human serum albumin
  • tumor necrosis factors

ASJC Scopus subject areas

  • Biomaterials
  • Engineering (miscellaneous)
  • Biotechnology
  • Medicine(all)

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