Abstract
We report a case of herpetic brainstem encephalitis (HBE) retrospectively diagnosed in an adult patient. Conventional immunovirological studies failed to disclose the etiology of this patient's affection. An isoelectric focusing-antigen overlay (IEF-O) technique showed that the target of one of the four cerebrospinal fluid oligoclonal bands was herpes simplex virus (HSV)-1 glycoprotein B, indicating a specific anti-HSV immunoresponse restricted to the CNS. IEF-O may represent a useful support for in vivo diagnosis of HBE.
| Original language | English |
|---|---|
| Pages (from-to) | 364-367 |
| Number of pages | 4 |
| Journal | Acta Neurologica Scandinavica |
| Volume | 82 |
| Issue number | 6 |
| Publication status | Published - 1990 |
Fingerprint
Keywords
- brainstem encephalitis
- herpes simplex virus type 1
- isoelectric focusing antigen overlay
- oligoclonal bands
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
Cite this
Isoelectric focusing herpes simplex virus-gB overlay study in brainstem encephalitis. / Martino, G. V.; Grimaldi, L. M E; Franciotta, D. M.; Piccolo, G.; Brustia, R.; Minoli, L.; Melzi d'Eril, G. V.
In: Acta Neurologica Scandinavica, Vol. 82, No. 6, 1990, p. 364-367.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Isoelectric focusing herpes simplex virus-gB overlay study in brainstem encephalitis
AU - Martino, G. V.
AU - Grimaldi, L. M E
AU - Franciotta, D. M.
AU - Piccolo, G.
AU - Brustia, R.
AU - Minoli, L.
AU - Melzi d'Eril, G. V.
PY - 1990
Y1 - 1990
N2 - We report a case of herpetic brainstem encephalitis (HBE) retrospectively diagnosed in an adult patient. Conventional immunovirological studies failed to disclose the etiology of this patient's affection. An isoelectric focusing-antigen overlay (IEF-O) technique showed that the target of one of the four cerebrospinal fluid oligoclonal bands was herpes simplex virus (HSV)-1 glycoprotein B, indicating a specific anti-HSV immunoresponse restricted to the CNS. IEF-O may represent a useful support for in vivo diagnosis of HBE.
AB - We report a case of herpetic brainstem encephalitis (HBE) retrospectively diagnosed in an adult patient. Conventional immunovirological studies failed to disclose the etiology of this patient's affection. An isoelectric focusing-antigen overlay (IEF-O) technique showed that the target of one of the four cerebrospinal fluid oligoclonal bands was herpes simplex virus (HSV)-1 glycoprotein B, indicating a specific anti-HSV immunoresponse restricted to the CNS. IEF-O may represent a useful support for in vivo diagnosis of HBE.
KW - brainstem encephalitis
KW - herpes simplex virus type 1
KW - isoelectric focusing antigen overlay
KW - oligoclonal bands
UR - http://www.scopus.com/inward/record.url?scp=0025604710&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025604710&partnerID=8YFLogxK
M3 - Article
C2 - 2291396
AN - SCOPUS:0025604710
VL - 82
SP - 364
EP - 367
JO - Acta Neurologica Scandinavica
JF - Acta Neurologica Scandinavica
SN - 0001-6314
IS - 6
ER -