Isoelectric focusing herpes simplex virus-gB overlay study in brainstem encephalitis

G. V. Martino; L. M E Grimaldi; D. M. Franciotta; G. Piccolo; R. Brustia; L. Minoli; G. V. Melzi d'Eril

Isoelectric focusing herpes simplex virus-gB overlay study in brainstem encephalitis

G. V. Martino, L. M E Grimaldi, D. M. Franciotta, G. Piccolo, R. Brustia, L. Minoli, G. V. Melzi d'Eril

Research output: Contribution to journal › Article › peer-review

Abstract

We report a case of herpetic brainstem encephalitis (HBE) retrospectively diagnosed in an adult patient. Conventional immunovirological studies failed to disclose the etiology of this patient's affection. An isoelectric focusing-antigen overlay (IEF-O) technique showed that the target of one of the four cerebrospinal fluid oligoclonal bands was herpes simplex virus (HSV)-1 glycoprotein B, indicating a specific anti-HSV immunoresponse restricted to the CNS. IEF-O may represent a useful support for in vivo diagnosis of HBE.

Original language	English
Pages (from-to)	364-367
Number of pages	4
Journal	Acta Neurologica Scandinavica
Volume	82
Issue number	6
Publication status	Published - 1990

Keywords

brainstem encephalitis
herpes simplex virus type 1
isoelectric focusing antigen overlay
oligoclonal bands

ASJC Scopus subject areas

Clinical Neurology
Neuroscience(all)

Cite this

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title = "Isoelectric focusing herpes simplex virus-gB overlay study in brainstem encephalitis",

abstract = "We report a case of herpetic brainstem encephalitis (HBE) retrospectively diagnosed in an adult patient. Conventional immunovirological studies failed to disclose the etiology of this patient's affection. An isoelectric focusing-antigen overlay (IEF-O) technique showed that the target of one of the four cerebrospinal fluid oligoclonal bands was herpes simplex virus (HSV)-1 glycoprotein B, indicating a specific anti-HSV immunoresponse restricted to the CNS. IEF-O may represent a useful support for in vivo diagnosis of HBE.",

keywords = "brainstem encephalitis, herpes simplex virus type 1, isoelectric focusing antigen overlay, oligoclonal bands",

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AU - Martino, G. V.

AU - Grimaldi, L. M E

AU - Franciotta, D. M.

AU - Piccolo, G.

AU - Brustia, R.

AU - Minoli, L.

AU - Melzi d'Eril, G. V.

PY - 1990

Y1 - 1990

N2 - We report a case of herpetic brainstem encephalitis (HBE) retrospectively diagnosed in an adult patient. Conventional immunovirological studies failed to disclose the etiology of this patient's affection. An isoelectric focusing-antigen overlay (IEF-O) technique showed that the target of one of the four cerebrospinal fluid oligoclonal bands was herpes simplex virus (HSV)-1 glycoprotein B, indicating a specific anti-HSV immunoresponse restricted to the CNS. IEF-O may represent a useful support for in vivo diagnosis of HBE.

AB - We report a case of herpetic brainstem encephalitis (HBE) retrospectively diagnosed in an adult patient. Conventional immunovirological studies failed to disclose the etiology of this patient's affection. An isoelectric focusing-antigen overlay (IEF-O) technique showed that the target of one of the four cerebrospinal fluid oligoclonal bands was herpes simplex virus (HSV)-1 glycoprotein B, indicating a specific anti-HSV immunoresponse restricted to the CNS. IEF-O may represent a useful support for in vivo diagnosis of HBE.

KW - brainstem encephalitis

KW - herpes simplex virus type 1

KW - isoelectric focusing antigen overlay

KW - oligoclonal bands

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Isoelectric focusing herpes simplex virus-gB overlay study in brainstem encephalitis

Abstract

Keywords

ASJC Scopus subject areas

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