Isoenzymic analysis of fifteen non-lysosomal enzymes in human chorionic villi

G. Novelli, F. Catizone, B. Dallapiccola

Research output: Contribution to journalArticlepeer-review

Abstract

The electrophoretic pattern of 15 non-lysosomal enzymes was established in human chorionic villi sampled at 8-12 weeks of gestation from 30 women requesting legal abortion. The product of 23 genes was detected at this stage of development. Trophoblast cells are mitotic derivates from the zygote. Thus, chorionic villi have the same genetic constitution as the embryo. Establishing the normal isoenzymatic patterns in fetal life is of wide theoretical and biological interest. In particular, it contributes to the understanding of gene modulation and the differential activity of alleloenzymes during early embryogenesis and development. In addition, the possibility is suggested that in the future electrophoresis analysis can be used in conjunction with quantitative enzyme assay for the fetal diagnosis of specific metabolic disorders involving one or more isoenzymes.

Original languageEnglish
Pages (from-to)36-42
Number of pages7
JournalBiology of the Neonate
Volume50
Issue number1
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Developmental Biology
  • Pediatrics, Perinatology, and Child Health

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