Isoforms of the Na,K-ATPase are present in both axons and dendrites of hippocampal neurons in culture

Grazia Pietrini, Michela Matteoli, Gary Banker, Michael J. Caplan

Research output: Contribution to journalArticle

Abstract

The distributions of isoforms of the Na,K-ATPase a subunit were determined in mature cultured hippocampal neurons and in a polarized epithelial cell line. We find that hippocampal neurons express the α1 and α3 isoforms in the membranes of both axons and dendrites. In contrast the al and α3 proteins are exclusively basolateral when expressed endogenously or by stable transfection in renal epithelial cells. These data suggest that epithelial cells and hippocampal neurons localize these proteins by different mechanisms. These observations contrast with those made for the vesicular stomatitis virus and the influenza glycoproteins, which are polarized in both epithelial and neuronal cells.

Original languageEnglish
Pages (from-to)8415-8418
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume89
Issue number18
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Genetics
  • General

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