Isolated aortitis versus giant cell arteritis: Are they really two sides of the same coin?

Rosaria Talarico, Luigi Boiardi, Nicolò Pipitone, Anna D'Ascanio, Chiara Stagnaro, Claudia Ferrari, Elena Elefante, Carlo Salvarani, Stefano Bombardieri

Research output: Contribution to journalArticlepeer-review


Objective: The aim of the study was to compare epidemiological data, clinical findings and results of investigations in patients with isolated aortitis and those with giant cell arteritis (GCA) to establish whether patients with isolated aortitis differ from those with GCA. Patients and methods: We reviewed the medical notes of all patients consecutively seen in two Rheumatology centres in the last two decades with a suspicion of GCA, searching for cases characterised by abnormal [18F] fluorodeoxyglucose (FDG) PET uptake of the aorta. "Isolated aortitis" was defined as increased FDG uptake in the aorta not explained by atherosclerosis in the absence of FDG uptake in other large vessels. Results: Comparing the epidemiological and clinical data of patients with isolated arteritis with those with GCA, we observed many statistical significant differences. First of all, the male/female ratio was reversed, with a predominant male involvement in isolated arteritis. Moreover, the mean age of patients with isolated arteritis was significantly lower than that of GCA patients (62 vs. 78.4 yrs; p

Original languageEnglish
JournalClinical and Experimental Rheumatology
Issue numberSUPPL.82
Publication statusPublished - 2014


  • Giant cell arteritis
  • Isolated aortitis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy

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