Abstract
Background: Isolated bone marrow non-Hodgkin's lymphoma (NHL) is rare, and determining the diagnosis is difficult. Patients: We describe four patients with apparent isolated bone marrow NHL. The features they had in common included fever, abnormal liver function, pancytopenia, polyserositis, neurologic symptoms, opportunistic infections, and a short, fatal course. Findings: Routine cytologic and histologic studies showed intermediate and large lymphomatous cells in the bone marrow, with a predominantly interstitial pattern. Immunophenotyping revealed three cases of T-cell and one case of B-cell NHL. Cytogenetic analysis demonstrated an abnormal clone in two patients. Conclusion: The diagnosis of isolated bone marrow NHL should be based on the examination of both bone marrow aspirates and biopsy specimens.
| Original language | English |
|---|---|
| Pages (from-to) | 37-43 |
| Number of pages | 7 |
| Journal | Mayo Clinic Proceedings |
| Volume | 69 |
| Issue number | 1 |
| Publication status | Published - 1994 |
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ASJC Scopus subject areas
- Medicine(all)
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Isolated bone marrow non-Hodgkin's lymphoma : A clinicopathologic study. / Ponzoni, M.; Li, C. Y.
In: Mayo Clinic Proceedings, Vol. 69, No. 1, 1994, p. 37-43.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Isolated bone marrow non-Hodgkin's lymphoma
T2 - A clinicopathologic study
AU - Ponzoni, M.
AU - Li, C. Y.
PY - 1994
Y1 - 1994
N2 - Background: Isolated bone marrow non-Hodgkin's lymphoma (NHL) is rare, and determining the diagnosis is difficult. Patients: We describe four patients with apparent isolated bone marrow NHL. The features they had in common included fever, abnormal liver function, pancytopenia, polyserositis, neurologic symptoms, opportunistic infections, and a short, fatal course. Findings: Routine cytologic and histologic studies showed intermediate and large lymphomatous cells in the bone marrow, with a predominantly interstitial pattern. Immunophenotyping revealed three cases of T-cell and one case of B-cell NHL. Cytogenetic analysis demonstrated an abnormal clone in two patients. Conclusion: The diagnosis of isolated bone marrow NHL should be based on the examination of both bone marrow aspirates and biopsy specimens.
AB - Background: Isolated bone marrow non-Hodgkin's lymphoma (NHL) is rare, and determining the diagnosis is difficult. Patients: We describe four patients with apparent isolated bone marrow NHL. The features they had in common included fever, abnormal liver function, pancytopenia, polyserositis, neurologic symptoms, opportunistic infections, and a short, fatal course. Findings: Routine cytologic and histologic studies showed intermediate and large lymphomatous cells in the bone marrow, with a predominantly interstitial pattern. Immunophenotyping revealed three cases of T-cell and one case of B-cell NHL. Cytogenetic analysis demonstrated an abnormal clone in two patients. Conclusion: The diagnosis of isolated bone marrow NHL should be based on the examination of both bone marrow aspirates and biopsy specimens.
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M3 - Article
VL - 69
SP - 37
EP - 43
JO - Mayo Clinic Proceedings
JF - Mayo Clinic Proceedings
SN - 0025-6196
IS - 1
ER -