TY - JOUR
T1 - Isolated bone marrow non-Hodgkin's lymphoma
T2 - A clinicopathologic study
AU - Ponzoni, M.
AU - Li, C. Y.
PY - 1994
Y1 - 1994
N2 - Background: Isolated bone marrow non-Hodgkin's lymphoma (NHL) is rare, and determining the diagnosis is difficult. Patients: We describe four patients with apparent isolated bone marrow NHL. The features they had in common included fever, abnormal liver function, pancytopenia, polyserositis, neurologic symptoms, opportunistic infections, and a short, fatal course. Findings: Routine cytologic and histologic studies showed intermediate and large lymphomatous cells in the bone marrow, with a predominantly interstitial pattern. Immunophenotyping revealed three cases of T-cell and one case of B-cell NHL. Cytogenetic analysis demonstrated an abnormal clone in two patients. Conclusion: The diagnosis of isolated bone marrow NHL should be based on the examination of both bone marrow aspirates and biopsy specimens.
AB - Background: Isolated bone marrow non-Hodgkin's lymphoma (NHL) is rare, and determining the diagnosis is difficult. Patients: We describe four patients with apparent isolated bone marrow NHL. The features they had in common included fever, abnormal liver function, pancytopenia, polyserositis, neurologic symptoms, opportunistic infections, and a short, fatal course. Findings: Routine cytologic and histologic studies showed intermediate and large lymphomatous cells in the bone marrow, with a predominantly interstitial pattern. Immunophenotyping revealed three cases of T-cell and one case of B-cell NHL. Cytogenetic analysis demonstrated an abnormal clone in two patients. Conclusion: The diagnosis of isolated bone marrow NHL should be based on the examination of both bone marrow aspirates and biopsy specimens.
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M3 - Article
C2 - 8271848
AN - SCOPUS:0028082244
VL - 69
SP - 37
EP - 43
JO - Mayo Clinic Proceedings
JF - Mayo Clinic Proceedings
SN - 0025-6196
IS - 1
ER -