Isolated brain metastasis of malignant choroidal melanoma 27 years after enucleation

Edoardo Midena, Valentina De Belvis, Angela P. Dei Tos, Cristina Antonini

Research output: Contribution to journalArticlepeer-review


Choroidal melanoma primarily metastasizes to the liver. Isolated extrahepatic metastases have rarely been reported and they generally resulted in death within 6 months. We describe a patient who developed an isolated brain metastasis 27 years after his left eye was enucleated for choroidal melanoma. The metastasis was successfully treated with surgery and radiotherapy. The patient is alive and disease free 3 years after treatment of the metastasis. Posterior location and other clinical and morphologic characteristics of primary choroidal melanoma could explain the unusually long latency of this solitary extrahepatic metastatic disease. Lifelong surveillance to detect early signs of metastasis is mandatory for any patient treated for choroidal melanoma.

Original languageEnglish
Pages (from-to)1553-1556
Number of pages4
JournalArchives of Ophthalmology
Issue number11
Publication statusPublished - Nov 1999

ASJC Scopus subject areas

  • Ophthalmology


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