Isolated head tremor: A DAT-SPECT and somatosensory temporal discrimination study

Gina Ferrazzano; Viviana Frantellizzi; Maria Ilenia De Bartolo; Maria Silvia De Feo; Antonella Conte; Giovanni Fabbrini; Giuseppe De Vincentis; Alfredo Berardelli

doi:10.1016/j.parkreldis.2020.10.015

Isolated head tremor: A DAT-SPECT and somatosensory temporal discrimination study

Gina Ferrazzano, Viviana Frantellizzi, Maria Ilenia De Bartolo, Maria Silvia De Feo, Antonella Conte, Giovanni Fabbrini, Giuseppe De Vincentis, Alfredo Berardelli

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Abstract

INTRODUCTION: To better understand the pathophysiology of isolated head tremor, we investigated somatosensory temporal discrimination threshold (STDT) and dopaminergic neurotransmission with 123I-FP-CIT (DAT-SPECT) in patients with isolated head tremor, as well as potential correlations with their clinical features.

METHODS: We enrolled 14 patients with isolated head tremor who underwent clinical examination, STDT testing, and DAT-SPECT.

RESULTS: We found normal radiotracer uptake in both striata as assessed with DAT-SPECT examination, but higher STDT values in patients as compared to healthy subjects. No significant correlations emerged between STDT values, specific binding ratios of radiotracer uptake, and demographic or clinical features.

CONCLUSION: Our study found normal radiotracer uptake with DAT-SPECT examination, suggesting dopaminergic neurotransmission integrity in patients with isolated head tremor. Patients with isolated head tremor exhibited an abnormally elevated STDT. Both results support the hypothesis that isolated head tremor should be considered a form of dystonia.

Original language	English
Pages (from-to)	56-59
Number of pages	4
Journal	Parkinsonism and Related Disorders
Volume	81
DOIs	https://doi.org/10.1016/j.parkreldis.2020.10.015
Publication status	E-pub ahead of print - Oct 9 2020

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Isolated head tremor : A DAT-SPECT and somatosensory temporal discrimination study. / Ferrazzano, Gina; Frantellizzi, Viviana; De Bartolo, Maria Ilenia; De Feo, Maria Silvia; Conte, Antonella ; Fabbrini, Giovanni; De Vincentis, Giuseppe; Berardelli, Alfredo.

In: Parkinsonism and Related Disorders, Vol. 81, 09.10.2020, p. 56-59.

Research output: Contribution to journal › Article › peer-review

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title = "Isolated head tremor: A DAT-SPECT and somatosensory temporal discrimination study",

abstract = "INTRODUCTION: To better understand the pathophysiology of isolated head tremor, we investigated somatosensory temporal discrimination threshold (STDT) and dopaminergic neurotransmission with 123I-FP-CIT (DAT-SPECT) in patients with isolated head tremor, as well as potential correlations with their clinical features.METHODS: We enrolled 14 patients with isolated head tremor who underwent clinical examination, STDT testing, and DAT-SPECT.RESULTS: We found normal radiotracer uptake in both striata as assessed with DAT-SPECT examination, but higher STDT values in patients as compared to healthy subjects. No significant correlations emerged between STDT values, specific binding ratios of radiotracer uptake, and demographic or clinical features.CONCLUSION: Our study found normal radiotracer uptake with DAT-SPECT examination, suggesting dopaminergic neurotransmission integrity in patients with isolated head tremor. Patients with isolated head tremor exhibited an abnormally elevated STDT. Both results support the hypothesis that isolated head tremor should be considered a form of dystonia.",

author = "Gina Ferrazzano and Viviana Frantellizzi and {De Bartolo}, {Maria Ilenia} and {De Feo}, {Maria Silvia} and Antonella Conte and Giovanni Fabbrini and {De Vincentis}, Giuseppe and Alfredo Berardelli",

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AU - Ferrazzano, Gina

AU - Frantellizzi, Viviana

AU - De Bartolo, Maria Ilenia

AU - De Feo, Maria Silvia

AU - Conte, Antonella

AU - Fabbrini, Giovanni

AU - De Vincentis, Giuseppe

AU - Berardelli, Alfredo

PY - 2020/10/9

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N2 - INTRODUCTION: To better understand the pathophysiology of isolated head tremor, we investigated somatosensory temporal discrimination threshold (STDT) and dopaminergic neurotransmission with 123I-FP-CIT (DAT-SPECT) in patients with isolated head tremor, as well as potential correlations with their clinical features.METHODS: We enrolled 14 patients with isolated head tremor who underwent clinical examination, STDT testing, and DAT-SPECT.RESULTS: We found normal radiotracer uptake in both striata as assessed with DAT-SPECT examination, but higher STDT values in patients as compared to healthy subjects. No significant correlations emerged between STDT values, specific binding ratios of radiotracer uptake, and demographic or clinical features.CONCLUSION: Our study found normal radiotracer uptake with DAT-SPECT examination, suggesting dopaminergic neurotransmission integrity in patients with isolated head tremor. Patients with isolated head tremor exhibited an abnormally elevated STDT. Both results support the hypothesis that isolated head tremor should be considered a form of dystonia.

AB - INTRODUCTION: To better understand the pathophysiology of isolated head tremor, we investigated somatosensory temporal discrimination threshold (STDT) and dopaminergic neurotransmission with 123I-FP-CIT (DAT-SPECT) in patients with isolated head tremor, as well as potential correlations with their clinical features.METHODS: We enrolled 14 patients with isolated head tremor who underwent clinical examination, STDT testing, and DAT-SPECT.RESULTS: We found normal radiotracer uptake in both striata as assessed with DAT-SPECT examination, but higher STDT values in patients as compared to healthy subjects. No significant correlations emerged between STDT values, specific binding ratios of radiotracer uptake, and demographic or clinical features.CONCLUSION: Our study found normal radiotracer uptake with DAT-SPECT examination, suggesting dopaminergic neurotransmission integrity in patients with isolated head tremor. Patients with isolated head tremor exhibited an abnormally elevated STDT. Both results support the hypothesis that isolated head tremor should be considered a form of dystonia.

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