Isolated limb perfusion for soft tissue sarcoma: Current practices and future directions. A survey of experts and a review of literature.

K. S. Martin-Tellez, W. J. van Houdt, F. van Coevorden, C. Colombo, M. Fiore

Research output: Contribution to journalArticlepeer-review

Abstract

Soft tissue sarcomas constitute 10 different histologic types. Isolated limb perfusion is an established treatment strategy for locally advanced sarcomas. Since its adoption for sarcomas in 1992, after the addition of TNFα, few modifications have been done and although indications for the procedure are essentially the same across centers, technical details vary widely. The procedures mainly involves a 60 min perfusion with melphalan and TNFα under mild hyperthermia, achieving a limb preservation rate of 72-96 with an overall response rates from 72 to 82.574-31 months compared to 402-22 months. Currently there is no consensus regarding the benefit of ILP per histotype, and the value of addition of radiotherapy or systemic treatment. Further developments towards individualized treatments will provide a better understanding of the population that can derive maximum benefit of ILP with the least morbidity.
Original languageEnglish
JournalCancer Treatment Reviews
Publication statusPublished - Aug 1 2020

Fingerprint Dive into the research topics of 'Isolated limb perfusion for soft tissue sarcoma: Current practices and future directions. A survey of experts and a review of literature.'. Together they form a unique fingerprint.

Cite this