Isolated perfused liver

a model for studies on cancer-cell dissemination

A. Guaitani, J. Květina, S. Garattini

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The uptake of cancer cells by isolated perfused liver was studied as a model for cancer-cell dissemination. Ehrlich carcinoma or rhabdomyosarcoma BA 1112 cells were added to the perfusion medium and their disappearance was followed under various conditions. These studies indicated that: (a) cancer cells are repidly removed by circulation through the liver; (b) there is an increase in vascular resistance which is proportional to the number of cancer cells infused; (c) vasodilatation, induced by nitroglycerine, decreases the uptake of cancer cells by the liver; and (d) an increase of blood glucose and glutamic-oxalacetic transaminase and a decrease in the biliary flow occurs as a result of cancer-cell perfusion.

Original languageEnglish
Pages (from-to)79-84
Number of pages6
JournalEuropean Journal of Cancer (1965)
Volume8
Issue number1
DOIs
Publication statusPublished - 1972

Fingerprint

Liver
Neoplasms
Perfusion
Liver Circulation
Rhabdomyosarcoma
Nitroglycerin
Liver Neoplasms
Transaminases
Vasodilation
Vascular Resistance
Blood Glucose
Cell Count
Carcinoma

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Isolated perfused liver : a model for studies on cancer-cell dissemination. / Guaitani, A.; Květina, J.; Garattini, S.

In: European Journal of Cancer (1965), Vol. 8, No. 1, 1972, p. 79-84.

Research output: Contribution to journalArticle

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