Isolated perfused liver: a model for studies on cancer-cell dissemination

A. Guaitani, J. Květina, S. Garattini

Research output: Contribution to journalArticlepeer-review


The uptake of cancer cells by isolated perfused liver was studied as a model for cancer-cell dissemination. Ehrlich carcinoma or rhabdomyosarcoma BA 1112 cells were added to the perfusion medium and their disappearance was followed under various conditions. These studies indicated that: (a) cancer cells are repidly removed by circulation through the liver; (b) there is an increase in vascular resistance which is proportional to the number of cancer cells infused; (c) vasodilatation, induced by nitroglycerine, decreases the uptake of cancer cells by the liver; and (d) an increase of blood glucose and glutamic-oxalacetic transaminase and a decrease in the biliary flow occurs as a result of cancer-cell perfusion.

Original languageEnglish
Pages (from-to)79-84
Number of pages6
JournalEuropean Journal of Cancer (1965)
Issue number1
Publication statusPublished - 1972

ASJC Scopus subject areas

  • Medicine(all)


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