Abstract
The uptake of cancer cells by isolated perfused liver was studied as a model for cancer-cell dissemination. Ehrlich carcinoma or rhabdomyosarcoma BA 1112 cells were added to the perfusion medium and their disappearance was followed under various conditions. These studies indicated that: (a) cancer cells are repidly removed by circulation through the liver; (b) there is an increase in vascular resistance which is proportional to the number of cancer cells infused; (c) vasodilatation, induced by nitroglycerine, decreases the uptake of cancer cells by the liver; and (d) an increase of blood glucose and glutamic-oxalacetic transaminase and a decrease in the biliary flow occurs as a result of cancer-cell perfusion.
| Original language | English |
|---|---|
| Pages (from-to) | 79-84 |
| Number of pages | 6 |
| Journal | European Journal of Cancer (1965) |
| Volume | 8 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1972 |
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Isolated perfused liver : a model for studies on cancer-cell dissemination. / Guaitani, A.; Květina, J.; Garattini, S.
In: European Journal of Cancer (1965), Vol. 8, No. 1, 1972, p. 79-84.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Isolated perfused liver
T2 - a model for studies on cancer-cell dissemination
AU - Guaitani, A.
AU - Květina, J.
AU - Garattini, S.
PY - 1972
Y1 - 1972
N2 - The uptake of cancer cells by isolated perfused liver was studied as a model for cancer-cell dissemination. Ehrlich carcinoma or rhabdomyosarcoma BA 1112 cells were added to the perfusion medium and their disappearance was followed under various conditions. These studies indicated that: (a) cancer cells are repidly removed by circulation through the liver; (b) there is an increase in vascular resistance which is proportional to the number of cancer cells infused; (c) vasodilatation, induced by nitroglycerine, decreases the uptake of cancer cells by the liver; and (d) an increase of blood glucose and glutamic-oxalacetic transaminase and a decrease in the biliary flow occurs as a result of cancer-cell perfusion.
AB - The uptake of cancer cells by isolated perfused liver was studied as a model for cancer-cell dissemination. Ehrlich carcinoma or rhabdomyosarcoma BA 1112 cells were added to the perfusion medium and their disappearance was followed under various conditions. These studies indicated that: (a) cancer cells are repidly removed by circulation through the liver; (b) there is an increase in vascular resistance which is proportional to the number of cancer cells infused; (c) vasodilatation, induced by nitroglycerine, decreases the uptake of cancer cells by the liver; and (d) an increase of blood glucose and glutamic-oxalacetic transaminase and a decrease in the biliary flow occurs as a result of cancer-cell perfusion.
UR - http://www.scopus.com/inward/record.url?scp=0015289120&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0015289120&partnerID=8YFLogxK
U2 - 10.1016/0014-2964(72)90086-2
DO - 10.1016/0014-2964(72)90086-2
M3 - Article
C2 - 5014577
AN - SCOPUS:0015289120
VL - 8
SP - 79
EP - 84
JO - European Journal of Cancer
JF - European Journal of Cancer
SN - 0014-2964
IS - 1
ER -