Metastasi splenica isolata in un caso di adenocarcinoma del collo uterino. Caso clinico.

Translated title of the contribution: Isolated splenic metastasis in a case of adenocarcinoma of the uterine cervix. A clinical case

E. Campagnutta, A. Zarrelli, V. Stefanutti, M. Cimitan, F. Querin, C. Scarabelli

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The incidence of splenic metastasis, revealed during autopsy, from solid tumours varies from 1.6% to 30% with a mean of 7%. The clinical observation of splenic metastasis in patients with carcinoma of the exocervix is only occasionally reported. In the majority of cases metastasis appears 4 or 5 years after the onset of disease. The case reported here is the only example we have found in the literature relating to an adenocarcinoma of the uterine cervix which led to an isolated splenic metastasis. A 47-years-old patient underwent radical hysterectomy according to Meigs due to a stage 1B N0 G2 endocervical adenocarcinoma. The patient was subsequently reoperated due to pelvic recurrence and received radiotherapy. Almost five years after the first operation CT showed a suspected isolate splenic recidivation following pain in the left side. Hepatosplenic scintigraphy confirmed the presence of a large central cold area, with blurred edges, suggesting metastasis. The patient again underwent laparotomy: the volume of the spleen was found to be increased with the splenic hilum covered with neoplastic tissue. Splenectomy was performed. Abdomino-pelvic and retroperitoneal inspection showed no further signs of metastasis. Histological tests confirmed the massive metastasis of the adenocarcinoma in splenic parenchymal tissue which was relatively differentiated with a clear cell appearance. Seven months later the patient was again operated following intestinal occlusion due to numerous entero-enteric adhesions. During the course of surgery a micronodule was removed from the cholecystic serosa, apparently composed of fibrin; histological analysis proved that this micronodule was the site of glandular micrometastasis. The patient then began three cycles of chemotherapy with Adriamycin (60 mg/m2).(ABSTRACT TRUNCATED AT 250 WORDS)

Original languageItalian
Pages (from-to)667-670
Number of pages4
JournalMinerva Ginecologica
Volume44
Issue number12
Publication statusPublished - Dec 1992

Fingerprint

Cervix Uteri
Adenocarcinoma
Neoplasm Metastasis
Serous Membrane
Neoplasm Micrometastasis
Splenectomy
Gallbladder
Fibrin
Hysterectomy
Radionuclide Imaging
Doxorubicin
Laparotomy
Autopsy
Radiotherapy
Spleen
Observation
Carcinoma
Recurrence
Drug Therapy
Pain

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Campagnutta, E., Zarrelli, A., Stefanutti, V., Cimitan, M., Querin, F., & Scarabelli, C. (1992). Metastasi splenica isolata in un caso di adenocarcinoma del collo uterino. Caso clinico. Minerva Ginecologica, 44(12), 667-670.

Metastasi splenica isolata in un caso di adenocarcinoma del collo uterino. Caso clinico. / Campagnutta, E.; Zarrelli, A.; Stefanutti, V.; Cimitan, M.; Querin, F.; Scarabelli, C.

In: Minerva Ginecologica, Vol. 44, No. 12, 12.1992, p. 667-670.

Research output: Contribution to journalArticle

Campagnutta, E, Zarrelli, A, Stefanutti, V, Cimitan, M, Querin, F & Scarabelli, C 1992, 'Metastasi splenica isolata in un caso di adenocarcinoma del collo uterino. Caso clinico.', Minerva Ginecologica, vol. 44, no. 12, pp. 667-670.
Campagnutta E, Zarrelli A, Stefanutti V, Cimitan M, Querin F, Scarabelli C. Metastasi splenica isolata in un caso di adenocarcinoma del collo uterino. Caso clinico. Minerva Ginecologica. 1992 Dec;44(12):667-670.
Campagnutta, E. ; Zarrelli, A. ; Stefanutti, V. ; Cimitan, M. ; Querin, F. ; Scarabelli, C. / Metastasi splenica isolata in un caso di adenocarcinoma del collo uterino. Caso clinico. In: Minerva Ginecologica. 1992 ; Vol. 44, No. 12. pp. 667-670.
@article{a2e6735e553345bbb12e4430423c0baf,
title = "Metastasi splenica isolata in un caso di adenocarcinoma del collo uterino. Caso clinico.",
abstract = "The incidence of splenic metastasis, revealed during autopsy, from solid tumours varies from 1.6{\%} to 30{\%} with a mean of 7{\%}. The clinical observation of splenic metastasis in patients with carcinoma of the exocervix is only occasionally reported. In the majority of cases metastasis appears 4 or 5 years after the onset of disease. The case reported here is the only example we have found in the literature relating to an adenocarcinoma of the uterine cervix which led to an isolated splenic metastasis. A 47-years-old patient underwent radical hysterectomy according to Meigs due to a stage 1B N0 G2 endocervical adenocarcinoma. The patient was subsequently reoperated due to pelvic recurrence and received radiotherapy. Almost five years after the first operation CT showed a suspected isolate splenic recidivation following pain in the left side. Hepatosplenic scintigraphy confirmed the presence of a large central cold area, with blurred edges, suggesting metastasis. The patient again underwent laparotomy: the volume of the spleen was found to be increased with the splenic hilum covered with neoplastic tissue. Splenectomy was performed. Abdomino-pelvic and retroperitoneal inspection showed no further signs of metastasis. Histological tests confirmed the massive metastasis of the adenocarcinoma in splenic parenchymal tissue which was relatively differentiated with a clear cell appearance. Seven months later the patient was again operated following intestinal occlusion due to numerous entero-enteric adhesions. During the course of surgery a micronodule was removed from the cholecystic serosa, apparently composed of fibrin; histological analysis proved that this micronodule was the site of glandular micrometastasis. The patient then began three cycles of chemotherapy with Adriamycin (60 mg/m2).(ABSTRACT TRUNCATED AT 250 WORDS)",
author = "E. Campagnutta and A. Zarrelli and V. Stefanutti and M. Cimitan and F. Querin and C. Scarabelli",
year = "1992",
month = "12",
language = "Italian",
volume = "44",
pages = "667--670",
journal = "Minerva Ginecologica",
issn = "0026-4784",
publisher = "Edizioni Minerva Medica S.p.A.",
number = "12",

}

TY - JOUR

T1 - Metastasi splenica isolata in un caso di adenocarcinoma del collo uterino. Caso clinico.

AU - Campagnutta, E.

AU - Zarrelli, A.

AU - Stefanutti, V.

AU - Cimitan, M.

AU - Querin, F.

AU - Scarabelli, C.

PY - 1992/12

Y1 - 1992/12

N2 - The incidence of splenic metastasis, revealed during autopsy, from solid tumours varies from 1.6% to 30% with a mean of 7%. The clinical observation of splenic metastasis in patients with carcinoma of the exocervix is only occasionally reported. In the majority of cases metastasis appears 4 or 5 years after the onset of disease. The case reported here is the only example we have found in the literature relating to an adenocarcinoma of the uterine cervix which led to an isolated splenic metastasis. A 47-years-old patient underwent radical hysterectomy according to Meigs due to a stage 1B N0 G2 endocervical adenocarcinoma. The patient was subsequently reoperated due to pelvic recurrence and received radiotherapy. Almost five years after the first operation CT showed a suspected isolate splenic recidivation following pain in the left side. Hepatosplenic scintigraphy confirmed the presence of a large central cold area, with blurred edges, suggesting metastasis. The patient again underwent laparotomy: the volume of the spleen was found to be increased with the splenic hilum covered with neoplastic tissue. Splenectomy was performed. Abdomino-pelvic and retroperitoneal inspection showed no further signs of metastasis. Histological tests confirmed the massive metastasis of the adenocarcinoma in splenic parenchymal tissue which was relatively differentiated with a clear cell appearance. Seven months later the patient was again operated following intestinal occlusion due to numerous entero-enteric adhesions. During the course of surgery a micronodule was removed from the cholecystic serosa, apparently composed of fibrin; histological analysis proved that this micronodule was the site of glandular micrometastasis. The patient then began three cycles of chemotherapy with Adriamycin (60 mg/m2).(ABSTRACT TRUNCATED AT 250 WORDS)

AB - The incidence of splenic metastasis, revealed during autopsy, from solid tumours varies from 1.6% to 30% with a mean of 7%. The clinical observation of splenic metastasis in patients with carcinoma of the exocervix is only occasionally reported. In the majority of cases metastasis appears 4 or 5 years after the onset of disease. The case reported here is the only example we have found in the literature relating to an adenocarcinoma of the uterine cervix which led to an isolated splenic metastasis. A 47-years-old patient underwent radical hysterectomy according to Meigs due to a stage 1B N0 G2 endocervical adenocarcinoma. The patient was subsequently reoperated due to pelvic recurrence and received radiotherapy. Almost five years after the first operation CT showed a suspected isolate splenic recidivation following pain in the left side. Hepatosplenic scintigraphy confirmed the presence of a large central cold area, with blurred edges, suggesting metastasis. The patient again underwent laparotomy: the volume of the spleen was found to be increased with the splenic hilum covered with neoplastic tissue. Splenectomy was performed. Abdomino-pelvic and retroperitoneal inspection showed no further signs of metastasis. Histological tests confirmed the massive metastasis of the adenocarcinoma in splenic parenchymal tissue which was relatively differentiated with a clear cell appearance. Seven months later the patient was again operated following intestinal occlusion due to numerous entero-enteric adhesions. During the course of surgery a micronodule was removed from the cholecystic serosa, apparently composed of fibrin; histological analysis proved that this micronodule was the site of glandular micrometastasis. The patient then began three cycles of chemotherapy with Adriamycin (60 mg/m2).(ABSTRACT TRUNCATED AT 250 WORDS)

UR - http://www.scopus.com/inward/record.url?scp=0027014047&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027014047&partnerID=8YFLogxK

M3 - Articolo

VL - 44

SP - 667

EP - 670

JO - Minerva Ginecologica

JF - Minerva Ginecologica

SN - 0026-4784

IS - 12

ER -