Isolation and assessment of the in vitro anti-tumor activity of smenothiazole a and B, chlorinated thiazole-containing peptide/polyketides from the Caribbean sponge, Smenospongia aurea

Germana Esposito, Roberta Teta, Roberta Miceli, Luca S. Ceccarelli, Gerardo Della Sala, Rosa Camerlingo, Elena Irollo, Alfonso Mangoni, Giuseppe Pirozzi, Valeria Costantino

Research output: Contribution to journalArticlepeer-review

Abstract

The study of the secondary metabolites contained in the organic extract of Caribbean sponge Smenospongia aurea led to the isolation of smenothiazole A ( 3) and B (4), hybrid peptide/polyketide compounds. Assays performed using four solid tumor cell lines showed that smenothiazoles exert a potent cytotoxic activity at nanomolar levels, with selectivity over ovarian cancer cells and a pro-apoptotic mechanism.

Original languageEnglish
Pages (from-to)444-459
Number of pages16
JournalMarine Drugs
Volume13
Issue number1
DOIs
Publication statusPublished - Jan 1 2015

Keywords

  • Anti-tumor lead molecules
  • Apoptosis
  • Marine natural products
  • MTT assays
  • Smenamides
  • Smenospongia aurea
  • Solid tumor cell lines
  • Structure elucidation
  • Thiazole

ASJC Scopus subject areas

  • Drug Discovery

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