The isolation of a K562 cell line, K562(S)R, resistant to 1-β-D-arabinofuranosylcytosine (ara-C)-mediated erythroid induction, is described. Ara-C (10-50 μM) inhibits cell growth of K562(S)R cells but is not able to activate the program of erythroid induction. This failure is associated with the lack in the increase of accumulation of ε-globin and γ-globin mRNA sequences in ara-C-treated K562(S)R cells. This cell line could be of interest for studies focused on molecular mechanisms of activation of globin genes in K562 cells.
|Number of pages||6|
|Publication status||Published - 1989|
ASJC Scopus subject areas
- Cancer Research
- Cell Biology