Isolation and characterization of a K562 cell line resistant to 1-β-D-arabinofuranosylcytosine-mediated erythroid induction

G. Bianchi Scarra, P. Fiorentini, R. Gambari, C. Nastruzzi, R. Barbieri, M. Sessarego, R. Ravazzolo, C. Garre

Research output: Contribution to journalArticlepeer-review

Abstract

The isolation of a K562 cell line, K562(S)R, resistant to 1-β-D-arabinofuranosylcytosine (ara-C)-mediated erythroid induction, is described. Ara-C (10-50 μM) inhibits cell growth of K562(S)R cells but is not able to activate the program of erythroid induction. This failure is associated with the lack in the increase of accumulation of ε-globin and γ-globin mRNA sequences in ara-C-treated K562(S)R cells. This cell line could be of interest for studies focused on molecular mechanisms of activation of globin genes in K562 cells.

Original languageEnglish
Pages (from-to)859-864
Number of pages6
JournalExperimental Hematology
Volume17
Issue number8
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Genetics
  • Hematology
  • Oncology
  • Transplantation

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