Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma

Rossella Galli, Elena Binda, Ugo Orfanelli, Barbara Cipelletti, Angela Gritti, Simona De Vitis, Roberta Fiocco, Chiara Foroni, Francesco Dimeco, Angelo Vescovi

Research output: Contribution to journalArticle

Abstract

Transformed stem cells have been isolated from some human cancers. We report that, unlike other brain cancers, the lethal glioblastoma multiforme contains neural precursors endowed with all of the critical features expected from neural stem cells. Similar, yet not identical, to their normal neural stem cell counterpart, these precursors emerge as unipotent (astroglial) in vivo and multipotent (neuronal-astroglial-oligodendroglial) in culture. More importantly, these cells can act as tumor-founding cells down to the clonal level and can establish tumors that closely resemble the main histologic, cytologic, and architectural features of the human disease, even when challenged through serial transplantation. Thus, cells possessing all of the characteristics expected from tumor neural stem cells seem to be involved in the growth and recurrence of adult human glioblastomas multiforme.

Original languageEnglish
Pages (from-to)7011-7021
Number of pages11
JournalCancer Research
Volume64
Issue number19
DOIs
Publication statusPublished - Oct 1 2004

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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