Abstract
Hylamer polyethylene was used in the early 1990s to make hip-joint components. Clinical experience has shown that these components, if sterilized by gamma rays in the presence of oxygen, are easily affected by wear, which then leads to osteolysis. The authors analyzed polyethylene wear particles in seven patients who had received Hylamer polyethylene implants sterilized by gamma rays in air and had suffered prosthetic loosening. The results were compared to those of six controls, who had received traditional polyethylene implants, sterilized by the same method. The frequency distribution of globular and fibrillar particles was similar in both groups (38.5% in Hylamer, 45.2% in controls). The globular particles in the Hylamer samples had a mean area of 0.12 μm2, which was significantly lesser than that of the controls (0.30 μm2). The width of fibrillar particles in the Hylamer samples was significantly lesser than that of the controls. Therefore, the two materials, despite undergoing the same type of sterilization, produced different types of wear, due to their different properties. In conclusion, the difference in the morphology of Hylamer polyethylene wear particles in comparison with PCA might have caused a more intensive biological response, early and massive osteolysis, and therefore, early loosening.
| Original language | English |
|---|---|
| Pages (from-to) | 103-121 |
| Number of pages | 19 |
| Journal | Journal of Biomaterials Applications |
| Volume | 20 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Oct 2005 |
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Keywords
- Hylamer
- Polyethylene
- Scanning electron microscopy
- Wear
ASJC Scopus subject areas
- Biomedical Engineering
- Biomaterials
Cite this
Isolation and characterization of wear debris generated in patients wearing polyethylene Hylamer inserts, gamma irradiated in air. / Visentin, M.; Stea, S.; Squarzoni, S.; Reggiani, M.; Fagnano, C.; Antonietti, B.; Toni, A.
In: Journal of Biomaterials Applications, Vol. 20, No. 2, 10.2005, p. 103-121.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Isolation and characterization of wear debris generated in patients wearing polyethylene Hylamer inserts, gamma irradiated in air
AU - Visentin, M.
AU - Stea, S.
AU - Squarzoni, S.
AU - Reggiani, M.
AU - Fagnano, C.
AU - Antonietti, B.
AU - Toni, A.
PY - 2005/10
Y1 - 2005/10
N2 - Hylamer polyethylene was used in the early 1990s to make hip-joint components. Clinical experience has shown that these components, if sterilized by gamma rays in the presence of oxygen, are easily affected by wear, which then leads to osteolysis. The authors analyzed polyethylene wear particles in seven patients who had received Hylamer polyethylene implants sterilized by gamma rays in air and had suffered prosthetic loosening. The results were compared to those of six controls, who had received traditional polyethylene implants, sterilized by the same method. The frequency distribution of globular and fibrillar particles was similar in both groups (38.5% in Hylamer, 45.2% in controls). The globular particles in the Hylamer samples had a mean area of 0.12 μm2, which was significantly lesser than that of the controls (0.30 μm2). The width of fibrillar particles in the Hylamer samples was significantly lesser than that of the controls. Therefore, the two materials, despite undergoing the same type of sterilization, produced different types of wear, due to their different properties. In conclusion, the difference in the morphology of Hylamer polyethylene wear particles in comparison with PCA might have caused a more intensive biological response, early and massive osteolysis, and therefore, early loosening.
AB - Hylamer polyethylene was used in the early 1990s to make hip-joint components. Clinical experience has shown that these components, if sterilized by gamma rays in the presence of oxygen, are easily affected by wear, which then leads to osteolysis. The authors analyzed polyethylene wear particles in seven patients who had received Hylamer polyethylene implants sterilized by gamma rays in air and had suffered prosthetic loosening. The results were compared to those of six controls, who had received traditional polyethylene implants, sterilized by the same method. The frequency distribution of globular and fibrillar particles was similar in both groups (38.5% in Hylamer, 45.2% in controls). The globular particles in the Hylamer samples had a mean area of 0.12 μm2, which was significantly lesser than that of the controls (0.30 μm2). The width of fibrillar particles in the Hylamer samples was significantly lesser than that of the controls. Therefore, the two materials, despite undergoing the same type of sterilization, produced different types of wear, due to their different properties. In conclusion, the difference in the morphology of Hylamer polyethylene wear particles in comparison with PCA might have caused a more intensive biological response, early and massive osteolysis, and therefore, early loosening.
KW - Hylamer
KW - Polyethylene
KW - Scanning electron microscopy
KW - Wear
UR - http://www.scopus.com/inward/record.url?scp=27144440206&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=27144440206&partnerID=8YFLogxK
U2 - 10.1177/0885328205049407
DO - 10.1177/0885328205049407
M3 - Article
C2 - 16183672
AN - SCOPUS:27144440206
VL - 20
SP - 103
EP - 121
JO - Journal of Biomaterials Applications
JF - Journal of Biomaterials Applications
SN - 0885-3282
IS - 2
ER -