Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: Homology to Epstein-Barr virus open reading frame BCRFI

P. Vieira; R. De Waal-Malefyt; M. N. Dang; K. E. Johnson; R. Kastelein; D. F. Fiorentino; J. E. Devries; M. G. Roncarolo; T. R. Mosmann; K. W. Moore

Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: Homology to Epstein-Barr virus open reading frame BCRFI

P. Vieira, R. De Waal-Malefyt, M. N. Dang, K. E. Johnson, R. Kastelein, D. F. Fiorentino, J. E. Devries, M. G. Roncarolo, T. R. Mosmann, K. W. Moore

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

We have demonstrated the existence of human cytokine synthesis inhibitory factor (CSIF) [interleukin 10 (IL-10)]. cDNA clones encoding human IL-10 (hIL-10) were isolated from a tetanus toxin-specific human T-cell clone. Like mouse IL-10, hIL-10 exhibits strong DNA and amino acid sequence homology to an open reading frame in the Epstein-Barr virus, BCRFI. hIL-10 and the BCRFI product inhibit cytokine synthesis by activated human peripheral blood mononuclear cells and by a mouse Th1 clone. Both hIL-10 and mouse IL-10 sustain the viability of a mouse mast cell line in culture, but BCRFI lacks comparable activity in this assay, suggesting that BCRFI may have conserved only a subset of hIL-10 activities.

Original language	English
Pages (from-to)	1172-1176
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	88
Issue number	4
Publication status	Published - 1991

ASJC Scopus subject areas

General
Genetics

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Vieira, P., De Waal-Malefyt, R., Dang, M. N., Johnson, K. E., Kastelein, R., Fiorentino, D. F., Devries, J. E., Roncarolo, M. G., Mosmann, T. R., & Moore, K. W. (1991). Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: Homology to Epstein-Barr virus open reading frame BCRFI. Proceedings of the National Academy of Sciences of the United States of America, 88(4), 1172-1176.

Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones : Homology to Epstein-Barr virus open reading frame BCRFI. / Vieira, P.; De Waal-Malefyt, R.; Dang, M. N.; Johnson, K. E.; Kastelein, R.; Fiorentino, D. F.; Devries, J. E.; Roncarolo, M. G.; Mosmann, T. R.; Moore, K. W.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, No. 4, 1991, p. 1172-1176.

Research output: Contribution to journal › Article › peer-review

Vieira, P, De Waal-Malefyt, R, Dang, MN, Johnson, KE, Kastelein, R, Fiorentino, DF, Devries, JE, Roncarolo, MG, Mosmann, TR & Moore, KW 1991, 'Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: Homology to Epstein-Barr virus open reading frame BCRFI', Proceedings of the National Academy of Sciences of the United States of America, vol. 88, no. 4, pp. 1172-1176.

Vieira, P. ; De Waal-Malefyt, R. ; Dang, M. N. ; Johnson, K. E. ; Kastelein, R. ; Fiorentino, D. F. ; Devries, J. E. ; Roncarolo, M. G. ; Mosmann, T. R. ; Moore, K. W. / Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones : Homology to Epstein-Barr virus open reading frame BCRFI. In: Proceedings of the National Academy of Sciences of the United States of America. 1991 ; Vol. 88, No. 4. pp. 1172-1176.

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title = "Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: Homology to Epstein-Barr virus open reading frame BCRFI",

abstract = "We have demonstrated the existence of human cytokine synthesis inhibitory factor (CSIF) [interleukin 10 (IL-10)]. cDNA clones encoding human IL-10 (hIL-10) were isolated from a tetanus toxin-specific human T-cell clone. Like mouse IL-10, hIL-10 exhibits strong DNA and amino acid sequence homology to an open reading frame in the Epstein-Barr virus, BCRFI. hIL-10 and the BCRFI product inhibit cytokine synthesis by activated human peripheral blood mononuclear cells and by a mouse Th1 clone. Both hIL-10 and mouse IL-10 sustain the viability of a mouse mast cell line in culture, but BCRFI lacks comparable activity in this assay, suggesting that BCRFI may have conserved only a subset of hIL-10 activities.",

author = "P. Vieira and {De Waal-Malefyt}, R. and Dang, {M. N.} and Johnson, {K. E.} and R. Kastelein and Fiorentino, {D. F.} and Devries, {J. E.} and Roncarolo, {M. G.} and Mosmann, {T. R.} and Moore, {K. W.}",

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AU - Fiorentino, D. F.

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AU - Mosmann, T. R.

AU - Moore, K. W.

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AB - We have demonstrated the existence of human cytokine synthesis inhibitory factor (CSIF) [interleukin 10 (IL-10)]. cDNA clones encoding human IL-10 (hIL-10) were isolated from a tetanus toxin-specific human T-cell clone. Like mouse IL-10, hIL-10 exhibits strong DNA and amino acid sequence homology to an open reading frame in the Epstein-Barr virus, BCRFI. hIL-10 and the BCRFI product inhibit cytokine synthesis by activated human peripheral blood mononuclear cells and by a mouse Th1 clone. Both hIL-10 and mouse IL-10 sustain the viability of a mouse mast cell line in culture, but BCRFI lacks comparable activity in this assay, suggesting that BCRFI may have conserved only a subset of hIL-10 activities.

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