Isolation and Expression of the Homeobox Gene Gbx1 during Mouse Development

Muriel Rhinn, Klaus Lun, Michaela Werner, Antonio Simeone, Michael Brand

Research output: Contribution to journalArticlepeer-review


In zebrafish, gbx1 and otx2 are among the earliest genes expressed in the neuroectoderm, dividing it into an anterior and a posterior domain with a common border that marks the midbrain-hindbrain boundary (MHB) primordium. Here, we describe the sequence and expression pattern of Gbx1 in mouse. The first transcripts are found at embryonic day 7.75 in the hindbrain. Later on, expression of Gbx1 is detectable in the hindbrain (rhombomeres 2 to 7), spinal cord, optic vesicles, and in the ventral telencephalon. In mouse, Gbx1 expression is not observed at the MHB as is the case during early zebrafish development. We suggest that an evolutionary switch occurred: in mouse Gbx2 is involved in the early specification of the MHB primordium, whereas in zebrafish, gbx1 is required instead of gbx2.

Original languageEnglish
Pages (from-to)334-339
Number of pages6
JournalDevelopmental Dynamics
Issue number2
Publication statusPublished - Feb 2004


  • Gbx1
  • Gbx2
  • Hindbrain
  • Isthmus
  • MHB
  • Mouse
  • Organizer
  • Rhombomere
  • Zebrafish

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology


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