Isolation and partial purification of hepatic stimulatory substance

A. Francavilla, P. Ove, L. Polimeno, M. Coetzee, L. Makowka, M. Barone, D. H. Van Thiel, T. E. Starzl

Research output: Contribution to journalArticlepeer-review


The purpose of this study was to purify and characterize hepatic stimulatory substance (HSS), a protein found in the liver that has been reported to stimulate hepatic DNA synthesis and hepatocyte replication. HSS has been partially purified by successive steps, involving ethanol precipitation, ultrafiltration, and fast protein lipid chromatography (FPLC). The activity of this factor has been tested in 40% hepatectomized rats.

Original languageEnglish
Pages (from-to)719-721
Number of pages3
JournalTransplantation Proceedings
Issue number1 SUPPL. 1
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Surgery
  • Transplantation


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