Isolation and structure determination of enzymatically formed styrene oxide glutathione conjugates

J. Pachecka, P. Gariboldi, L. Cantoni, G. Belvedere, E. Mussini, M. Salmona

Research output: Contribution to journalArticle

Abstract

When styrene oxide was incubated with glutathione in the presence of rat liver cytosolic fraction, two conjugates were formed. Structural investigation by mass spectrometry (MS), proton magnetic resonance (PMR) analysis and chemical fragmentation showed the presence of two positional isomers, namely S-(1-phenyl-2-hydroxyethyl)glutathione and S-(2-phenyl-2-hydroxyethyl)glutathione in a ratio of approx. 60 : 40.

Original languageEnglish
Pages (from-to)313-321
Number of pages9
JournalChemico-Biological Interactions
Volume27
Issue number2-3
DOIs
Publication statusPublished - 1979

ASJC Scopus subject areas

  • Toxicology

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