Isolation of Flavonoids and Flavonoid Glycosides from Myrsine africana and Their Inhibitory Activities against Mushroom Tyrosinase

Navneet Kishore, Danielle Twilley, Analike Blom van Staden, Praveen Verma, Bikram Singh, Giorgia Cardinali, Daniela Kovacs, Mauro Picardo, Vivek Kumar, Namrita Lall

Research output: Contribution to journalArticlepeer-review

Abstract

Bioassay-guided fractionation of the methanol extract of the shoots of Myrsine africana led to the isolation of the new compound myricetin 3-O-(2″,4″-di-O-acetyl)-α-l-rhamnopyranoside (9) and 11 known compounds. The known compounds quercetin 3-O-(3″,4″-di-O-acetyl)-α-l-rhamnopyranoside (8), rutin (10), quercetin 3-O-α-l-rhamnopyranoside (11), and myricetin 3-O-α-l-rhamnopyranoside (12) are reported for the first time from the methanol extract of the shoots of M. africana. Compounds 10 and 12 showed significant inhibition of tyrosinase with 50% inhibition (IC50 values) of the enzyme at 0.13 ± 0.003 and 0.12 ± 0.002 mM, respectively, which was supported by the docking fitness scores obtained through molecular docking analysis. In addition, compounds 1-12 displayed significant antioxidant activity with IC50 values ranging 1.90 to 3.90 μM.

Original languageEnglish
Pages (from-to)49-56
Number of pages8
JournalJournal of Natural Products
Volume81
Issue number1
DOIs
Publication statusPublished - Jan 26 2018

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